Riboflavin Surface Modification of Poly(vinyl chloride) for Light-Triggered Control of Bacterial Biofilm and Virus Inactivation
Source abstract
Abstract
Poly(vinyl chloride) (PVC) is the most used biomedical polymer worldwide. PVC is a stable and chemically inert polymer. However, microorganisms can colonize PVC producing biomedical device-associated infections. While surface modifications of PVC can help improve the antimicrobial and antiviral properties, the chemically inert nature of PVC makes those modifications challenging and potentially toxic. In this work, we modified the PVC surface using a derivative riboflavin molecule that was chemically tethered to a plasma-treated PVC surface. Upon a low dosage of blue light, the riboflavin tethered to the PVC surface became photochemically activated, allowing for Pseudomonas aeruginosa bacterial biofilm and lentiviral in situ eradication.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Biosensors and Analytical Detection · Innovative Microfluidic and Catalytic Techniques Innovation · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
BEaTS Research, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario K1Y4W7, Canada
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
Ottawa-Carleton Institute for Biomedical Engineering, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
Department of Mechanical Engineering, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
Molecular Imaging Probes and Radiochemistry Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada
Institute of Chemistry, University of São Paulo, USP, São Paulo, SP 05508-000, Brazil
Departamento de Química Física, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago 7820244, Chile
Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine University of Ottawa, Ottawa, Ontario K1H8M5, Canada
Funding
Canadian Institutes of Health Research · Natural Sciences and Engineering Research Council of Canada
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