Fe-Porphyrin Cross-Linked Hydrogel for Reactive Oxygen Species Scavenging and Oxygen Generation in Diabetic Wounds

Min Ji Kim; Han Bi Ji; Chang Hee Min; Cho Rim Kim; Jae Hoon Han; Se-Na Kim; Soo Bin Yoon; Eun Jung Kwon; Cheol Lee; Young Bin Choy

doi:10.1021/acsami.4c00122

journal article·2024-03-27

Fe-Porphyrin Cross-Linked Hydrogel for Reactive Oxygen Species Scavenging and Oxygen Generation in Diabetic Wounds

Min Ji Kim, Han Bi Ji, Chang Hee Min, Cho Rim Kim, Jae Hoon Han, Se-Na Kim, Soo Bin Yoon, Eun Jung Kwon, Cheol Lee, Young Bin Choy

ACS Applied Materials & Interfaces· Volume 16· Issue 12

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Source abstract

Abstract

Healing chronic diabetic wounds is challenging because of excessive reactive oxygen species (ROS) and hypoxia in the wound microenvironment. To address this issue, we propose a hydrogel wound dressing composed of polyethylene glycol (PEG) cross-linked with a biomimetic catalase, Fe-containing porphyrin (FeP) (i.e., FeP hydrogel). The immobilized FeP can serve as a catalyst for both ROS scavenging and O 2 generation. The properties of the hydrogels were optimized by varying the composition ratios of the two constituent materials based on their mechanical properties and catalytic activity. Our in vitro cell experiments revealed that the FeP-80 hydrogel enhanced the proliferation and migration of keratinocytes and dermal fibroblasts and promoted the expression of angiogenic growth factors in keratinocytes. When tested with an in vivo diabetic chronic wound model, the FeP-80 hydrogel promoted wound healing by facilitating re-epithelialization, promoting angiogenesis, and suppressing inflammation, compared with other control groups.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Catalysis & surfaces

OpenAlex topics: Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management · Burn Injury Management and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea

Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea

Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul 03122, Republic of Korea

ToBIOs Inc., 3F, 9-7 Seongbuk-ro 5-gil, Seongbuk-gu, Seoul 02880, Republic of Korea

Funding

National Research Foundation of Korea · Ministry of Trade, Industry and Energy · Korea Institute for Advancement of Technology

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