DataVXACS Applied Materials & InterfacesPaper
journal article·2024-10-30

Precision Delivery of Binary Cooperative Nanodrugs Self-Assembled by Berberine Glycyrrhetinic Acid Salts for Hepatocellular Carcinoma Treatment

Yang Xiao, Alu Ouyang, Ling Fan, Xin Qin, Yu Li, Zixin Wang, Pingyun Yuan, Xuejing Huang, Jie Hao, Hongyan Zhu, Qiuju Huang, Hongwei Guo, Ronghua Jin

ACS Applied Materials & Interfaces· Volume 16· Issue 43
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Source abstract

Abstract

Berberine (BB) has demonstrated significant inhibitory effects on tumorigenesis and progression. However, its clinical application is hindered by challenges such as low bioavailability due to limited cell membrane permeability, nontargeted accumulation away from solid tumors, and increased toxicity associated with intravenous administration. To overcome these challenges, a lipophilic salt-forming strategy was employed to enhance lipophilicity, thereby promoting membrane permeability and targetability for tumor accumulation while simultaneously mitigating the toxicity associated with intravenous injection. In vitro findings revealed an almost 10-fold increase in fluorescence intensity with BB-GA NDs compared to BB alone. Furthermore, selective cytotoxicity against tumor cells exhibited a 4-fold elevation compared to normal cells. In vivo results underscored the remarkable tumor-selective accumulation of BB-GA NDs, effectively mitigating the intravenous injection toxicity associated with pure BB. The self-assembly of binary cooperative nanodrugs utilizing berberine glycyrrhetinic acid salts opens up innovative possibilities for drug delivery systems in traditional Chinese medicine.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Berberine and alkaloids research · Alkaloids: synthesis and pharmacology · Ginseng Biological Effects and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, Pharmaceutical College, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China

Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, P. R. China

Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering

Guangxi Minzu University

Shaanxi Key Laboratory of Biomedical Metal Materials

Northwest Institute for Nonferrous Metal Research

Department of Pharmaceutics, School of Pharmacy

Nantong University

Funding

Guangxi University for Nationalities · Guangxi Medical University · Guangxi Key Research and Development Program · Specific Research Project of Guangxi for Research Bases and Talents · Natural Science Foundation of Guangxi Zhuang Autonomous Region · Natural Science Basic Research Program of Shaanxi Province · National Natural Science Foundation of China · Youth Science Foundation of Guangxi Medical University · Guangxi Science and technology project · Guangxi Province University Young and Middle-aged Teachers Research Basic Research Capacity Improvement Project

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