journal article·2024-07-17

Multienzyme Active Nanozyme for Efficient Sepsis Therapy through Modulating Immune and Inflammation Inhibition

Qi Xin, Shaofang Zhang, Si Sun, Nan Song, Yadong Zhe, Fangzhen Tian, Shu Zhang, Meili Guo, Xiao-Dong Zhang, Jianning Zhang, Hao Wang, Ruiping Zhang

ACS Applied Materials & Interfaces· Volume 16· Issue 28
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Abstract

Sepsis, a life-threatening condition caused by a dysregulated immune response to infection, leads to systemic inflammation, immune dysfunction, and multiorgan damage. Various oxidoreductases play a very important role in balancing oxidative stress and modulating the immune response, but they are stored inconveniently, environmentally unstable, and expensive. Herein, we develop multifunctional artificial enzymes, CeO 2 and Au/CeO 2 nanozymes, exhibiting five distinct enzyme-like activities, namely, superoxide dismutase, catalase, glutathione peroxidase, peroxidase, and oxidase. These artificial enzymes have been used for the biocatalytic treatment of sepsis via inhibiting inflammation and modulating immune responses. These nanozymes significantly reduce reactive oxygen species and proinflammatory cytokines, achieving multiorgan protection. Notably, CeO 2 and Au/CeO 2 nanozymes with enzyme-mimicking activities can be particularly effective in restoring immunosuppression and maintaining homeostasis. The redox nanozyme offers a promising dual-protective strategy against sepsis-induced inflammation and organ dysfunction, paving the way for biocatalytic-based immunotherapies for sepsis and related inflammatory diseases.
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Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoparticles: synthesis and applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China

Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, China

Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China

Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China

Department of Neurosurgery and Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Tianjin Medical University General Hospital, Tianjin 300052, China

The Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Taiyuan 030032, China

Funding

National Key Research and Development Program of China · Tianjin University · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Tianjin Health Science and Technology Project · National Natural Science Foundation of Tianjin · Outstanding Youth Funds of Tianjin

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