Bottom-Up Fabrication of Large-Scale Gold Nanorod Arrays by Surface Diffusion-Mediated DNA Origami Assembly

Self-assembly of anisotropic metal nanoparticles serves as an effective bottom-up route for the nanofabrication of novel artifacts. However, there still are many challenges to rationally manipulate anisotropic particles due to the size and geometric restrictions. To avoid the aggregation and mishybridization from DNA sticky-end-guided assembly in buffer solution, in this work, we utilized a cation-controlled surface diffusion strategy to the spatial arrangement of gold nanorods (AuNRs) into 1D and 2D arrays by using DNA origami tiles as binding frames on the solid-liquid interface through π-π stacking interactions. To facilitate the further manipulation of those patterns, a novel pattern transfer method was introduced to transfer the arrays of AuNRs from a liquid to a dry ambient environment with high yield and minor structural damage. The results demonstrated a successful strategy of DNA origami-assisted, large-scale assembly of AuNRs for constructing complex superstructures with potential applications in the nanofabrication of plasmonic and electronic devices.