Smartphone Imaging Device for Multimodal Detection of Hydrogen Sulfide Using Cu-Doped MOF Sensors

Multimodal sensing platforms may offer reliable, fast results, but it is still challenging to incorporate biosensors with high discriminating ability in complex biological samples. Herein, we established a highly sensitive dual colorimetric/electrochemical monitoring approach for the detection of hydrogen sulfide (H 2 S) utilizing Cu-doped In-based metal–organic frameworks (Cu/In-MOFs) combined with a versatile color selector software-based smartphone imaging device. H 2 S can result in the enhancement of the electrochemical signal because of the electroactive substance copper sulfide (Cu x S), the decrease of the colorimetric signal of the characteristic absorption response caused by the strong coordination effect on Cu/In-MOFs, and the obvious changes of red-green-blue (RGB) values of images acquired via an intelligent smartphone. Attractively, the Cu/In-MOFs-based multimodal detection guarantees precise and sensitive detection of H 2 S with triple-signal detection limits of 0.096 μM (electrochemical signals), 0.098 μM (colorimetric signals), and 0.099 μM (smartphone signals) and an outstanding linear response. This analytical toolkit provides an idea for fabricating a robust, sensitive, tolerant matrix and reliable sensing platform for rapidly monitoring H 2 S in clinical disease diagnosis and visual supervision.