DataVXACS Applied Materials & InterfacesPaper
journal article·2024-02-28

Influence of Curvature on Cell Motility and Morphology during Cancer Migration in Confined Microchannels

Yan Liu, Tianyu Zhao, Zhao Xu, Ningman Dai, Qiang Zhao, Yutong Liang, Songmei Geng, Ming Lei, Feng Xu, Lin Wang, Bo Cheng

ACS Applied Materials & Interfaces· Volume 16· Issue 8
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Source abstract

Abstract

Microchannels often serve as highways for cancer migration, and their topology largely determines the migration efficiency. Curvature, a topological parameter in biological systems, has recently been reported to be efficient in guiding cell polarization and migration. Curvature varies widely along curved microchannels, while its influence on cell migration remains elusive. Here, we recapitulated the curved microchannels, as observed in clinical tumor tissues with hydrogels, and studied how cancer cells respond to curvature. We found that cells bend more significantly in a larger curvature and exhibit less spreading as well as lower motility. The underlying mechanism is probably based on the hindrance of the movement of cytoskeletal molecules at the curved microchannel walls. Collectively, our results demonstrated that the accelerated actin retrograde flow rate under local curvature has an effective negative regulation on cell motility and morphology, leading to shortened and bent cell morphologies as well as hampered cell migration efficiency.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Cellular Mechanics and Interactions · 3D Printing in Biomedical Research · Microtubule and mitosis dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Shaanxi 710049, PR China

Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Shaanxi 710049, PR China

MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an 710049, China

Department of Dermatology, The Second Affiliated Hospital, Xi’an Jiaotong University, Shaanxi 710049, PR China

College of Medicine, Xi’an International University, Xi’an, Shaanxi 710077, PR China

Engineering Research Center of Personalized Anti-aging Health Product Development and Transformation Universities of Shaanxi Province, Xi’an 710077, China

Funding

Shaanxi Key Science and Technology Innovation Team Project · National Natural Science Foundation of China · Key Research and Development Projects of Shaanxi Province · Innovation Capability Support Program of Shaanxi · Youth Innovation Team of Shaanxi Universities · Shaanxi Young Thousand Talents Plan

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