journal article·2022-12-21Open access

Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain

Tatiana N. Tikhonova, Dana Cohen-Gerassi, Zohar A. Arnon, Yuri Efremov, Peter Timashev, Lihi Adler-Abramovich, Evgeny A. Shirshin

ACS Applied Materials & Interfaces· Volume 14· Issue 50

Abstract

Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidity of the peptide hydrogel was employed as a marker of the temperature regime. The gelation kinetics under different conditions was studied to detect various stages of hydrogel structural transitions aimed at tuning the system properties. The developed sensor can be stored at room temperature for a long period, irreversibly indicates whether the product has been thawed, and can be adjusted to a specific temperature range and detection time.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · RNA Interference and Gene Delivery · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, M.V. Lomonosov Moscow State University, Leninskie gory 1/2, Moscow119991, Russia

SBIH Vorohobov’s City Clinical Hospital No. 67 MHD Moscow, 2/44 Salam Adil St., Moscow123423, Russia

Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, The Center for Nanoscience and Nanotechnology, The Center for the Physics and Chemistry of Living Systems, Tel Aviv University, Tel Aviv69978, Israel

World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University 8-2, Trubetskaya St., Moscow119991, Russia

Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya St., Moscow119991, Russia

Funding

Israel Science Foundation · Colton Foundation · Ministry of Science and Higher Education of the Russian Federation · Marian Gertner Institute for Medical Nano systems, Tel Aviv University

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