journal article·2022-08-10

A Shear-Thinning Biomaterial-Mediated Immune Checkpoint Blockade

Qingzhi Wu, Moyuan Qu, Han-Jun Kim, Xingwu Zhou, Xing Jiang, Yi Chen, Jixiang Zhu, Li Ren, Tyler Wolter, Heemin Kang, Chun Xu, Zhen Gu, Wujin Sun, Ali Khademhosseini

ACS Applied Materials & Interfaces· Volume 14· Issue 31
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Abstract

Systemic administration of immune checkpoint blockade agents can activate the anticancer activity of immune cells; however, the response varies from patient to patient and presents potential off-target toxicities. Local administration of immune checkpoint inhibitors (ICIs) can maximize therapeutic efficacies while reducing side effects. This study demonstrates a minimally invasive strategy to locally deliver anti-programmed cell death protein 1 (anti-PD-1) with shear-thinning biomaterials (STBs). ICI can be injected into tumors when loaded in STBs (STB-ICI) composed of gelatin and silicate nanoplatelets (Laponite). The release of ICI from STB was mainly affected by the Laponite percentage in STBs and pH of the local microenvironment. Low Laponite content and acidic pH can induce ICI release. In a murine melanoma model, the injection of STB-ICI significantly reduced tumor growth and increased CD8 + T cell level in peripheral blood. STB-ICI also induced increased levels of tumor-infiltrating CD4 + helper T cells, CD8 + cytotoxic T cells, and tumor death. The STB-based minimally invasive strategy provides a simple and efficient approach to deliver ICIs locally.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cancer Immunotherapy and Biomarkers · Nanoplatforms for cancer theranostics · Immune cells in cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering, Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States;

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P.R. China

Stomatology Hospital, School of Stomatology, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Clinical Research Center of Oral Disease of Zhejiang Province, Zhejiang University, Hangzhou 310006, P.R. China

Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States

Department of Pharmaceutic Science, University of Michigan, Ann Arbor, Michigan 48105, United States

School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China

The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, School of Biomedical Engineering, Guangzhou 511436, P.R. China

Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Northwestern Polytechnical University, Xi’an 710072, P.R. China

Academy of Integrated Science, Virginia Tech, Blacksburg, Virginia 24061, United States

Department of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea

School of Dentistry, The University of Queensland, Brisbane, QLD 4006, Australia

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.R. China

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, P.R. China

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P.R. China

Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, P.R. China

Jinhua Institute of Zhejiang University, Jinhua 321299, P.R. China

Department of Biological Systems Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States;

Department of Bioengineering, Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, Department of Chemical and Biomolecular Engineering, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California 90095, United States

Funding

National Heart, Lung, and Blood Institute · National Institute of Biomedical Imaging and Bioengineering

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