Multifunctional Yolk–Shell Mesoporous Silica Obtained via Selectively Etching the Shell: A Therapeutic Nanoplatform for Cancer Therapy

Herein, we fabricated a new yolk–shell-structured mesoporous silica nanoparticle (YMSN) with multifunctionalities of fluorescence imaging, photothermal therapy (PTT), and drug delivery by using a fluorescein isothiocyanate-doped silica nanoparticle partially covered by patchy gold as the core. Different from the conventional selective etching procedure, the multifunctional silica core is left intact, and the alkali etching mainly occurs in a hexadecyl trimethyl ammonium bromide/silica hybrid layer, which leads to the formation of the void space in YMSNs. In addition, the utilization of patchy gold as the PTT agent can avoid the shield against the outer irradiation on the core. Results show that the as-prepared YMSNs have a good biocompatibility in the concentration of 0–1000 μg·mL –1 and a high doxorubicin-loading capability (8.04 wt %). In vitro and in vivo antitumor experiments reveal that the resulting YMSNs can be utilized for chemo- and photothermic combination therapy as well as optical imaging.