journal article·2023-09-20

Dual-Conductive and Stiffness-Morphing Microneedle Patch Enables Continuous In Planta Monitoring of Electrophysiological Signal and Ion Fluctuation

Lingxuan Kong, Hanqi Wen, Yifei Luo, Xiaodong Chen, Xing Sheng, Yuxin Liu, Peng Chen

ACS Applied Materials & Interfaces· Volume 15· Issue 37
Publisher page

Abstract

The use of conductive microneedles presents a promising solution for achieving high-fidelity electrophysiological recordings with minimal impact on the interfaced tissue. However, a conventional metal-based microneedle suffers from high electrochemical impedance and mechanical mismatch. In this paper, we report a dual-conductive (i.e., both ionic and electronic conductive) and stiffness-morphing microneedle patch (DSMNP) for high-fidelity electrophysiological recordings with reduced tissue damage. The polymeric network of the DSMNP facilitates electrolyte absorption and therefore allows the transition of stiffness from 6.82 to 0.5139 N m –1 . Furthermore, the nanoporous conductive polymer increases the specific electrochemical surface area after tissue penetration, resulting in an ultralow specific impedance of 893.13 Ω mm 2 at 100 Hz. DSMNPs detect variation potential and action potential in real time and cation fluctuations in plants in response to environmental stimuli. After swelling, DSMNPs mechanically “lock” into biological tissues and prevent motion artifact by providing a stable interface. These results demonstrate the potential of DSMNPs for various applications in the field of plant physiology research and smart agriculture.
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Research context

OpenAlex topics: Plant and Biological Electrophysiology Studies · Neuroscience and Neural Engineering · Neurobiology and Insect Physiology Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637457, Singapore

Institute of Flexible Electronics Technology of THU, Jiaxing, Zhejiang 314000, China

Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore

Innovative Center for Flexible Devices (iFLEX), School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore

Institute for Digital Molecular Analytics and Science (IDMxS), Nanyang Technological University, Singapore 636921, Singapore

Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing 100084, China

Department of Biomedical Engineering, College of Design and Engineering, 4 Engineering Drive 3, National University of Singapore, Singapore 117583, Singapore

Institute for Health Innovation & TechnologyiHealthtech, National University of Singapore, Singapore 117599, Singapore

The N.1 Institute for Health, National University of Singapore, Singapore 117456, Singapore

Funding

Ministry of Education - Singapore · National University of Singapore · Nanyang Technological University · Qiantang Science and Technology Innovation Center

References (40)

Show source-provided references
1. 10.1038/s41467-018-06981-w10.1038/s41467-018-06981-w ↗
2. 10.1038/s41551-020-00672-y10.1038/s41551-020-00672-y ↗
3. 10.1002/smtd.20170026910.1002/smtd.201700269 ↗
4. 10.1016/j.bios.2022.11441210.1016/j.bios.2022.114412 ↗
5. 10.1038/s41551-019-0508-y10.1038/s41551-019-0508-y ↗
6. 10.1002/adma.20170224310.1002/adma.201702243 ↗
7. 10.1016/j.snb.2017.01.05210.1016/j.snb.2017.01.052 ↗
8. 10.3390/s2018518310.3390/s20185183 ↗
9. 10.1016/j.snb.2015.08.01310.1016/j.snb.2015.08.013 ↗
10. 10.1002/adma.20130449610.1002/adma.201304496 ↗
11. 10.1002/adma.20180581310.1002/adma.201805813 ↗
12. 10.1038/s41551-018-0335-610.1038/s41551-018-0335-6 ↗
13. 10.1002/adma.20180613310.1002/adma.201806133 ↗
14. 10.1002/adfm.20210568610.1002/adfm.202105686 ↗
15. 10.1039/C8TC00917A10.1039/C8TC00917A ↗
16. 10.3390/s14122375810.3390/s141223758 ↗
17. 10.1016/j.cjac.2022.10021110.1016/j.cjac.2022.100211 ↗
18. Degli Agosti R. · Arch. Sci. · 2014 · 67 · 125
19. 10.1002/adhm.20200191610.1002/adhm.202001916 ↗
20. 10.1021/acs.jpcb.8b0031710.1021/acs.jpcb.8b00317 ↗
21. 10.1039/C4RA09147G10.1039/C4RA09147G ↗
22. 10.1039/C5TC00276A10.1039/C5TC00276A ↗
23. 10.1039/c9tc06311k10.1039/c9tc06311k ↗
24. 10.1002/adma.20200784810.1002/adma.202007848 ↗
25. 10.1098/rsif.2012.034110.1098/rsif.2012.0341 ↗
26. 10.1111/j.1365-3040.2006.01614.x10.1111/j.1365-3040.2006.01614.x ↗
27. 10.3390/plants1008170410.3390/plants10081704 ↗
28. 10.1080/15592324.2015.105736510.1080/15592324.2015.1057365 ↗
29. 10.3389/fpls.2019.0139310.3389/fpls.2019.01393 ↗
30. 10.1073/pnas.190737911610.1073/pnas.1907379116 ↗
31. 10.1016/j.envexpbot.2014.06.01310.1016/j.envexpbot.2014.06.013 ↗
32. 10.1007/s00232-013-9529-810.1007/s00232-013-9529-8 ↗
33. 10.1093/aob/mcg16410.1093/aob/mcg164 ↗
34. 10.1016/j.kint.2017.09.01610.1016/j.kint.2017.09.016 ↗
35. 10.3390/nu1109197010.3390/nu11091970 ↗
36. 10.4161/psb.5.3.1074010.4161/psb.5.3.10740 ↗
37. 10.21769/bioprotoc.275810.21769/bioprotoc.2758 ↗
38. 10.1038/s41438-020-0315-310.1038/s41438-020-0315-3 ↗
39. 10.1111/j.1365-3040.1991.tb01538.x10.1111/j.1365-3040.1991.tb01538.x ↗
40. 10.1038/nature1652110.1038/nature16521 ↗