Light-Mediated Shape Transformation of a Self-Rolling Nanocomposite Hydrogel Tube

Self-rolling of a planar hydrogel sheet represents an advanced approach for fabricating a tubular construct, which is of significant interest in biomedicine. However, the self-rolling tube is usually lacking in remote controllability and requires a relatively tedious fabrication procedure. Herein, we present an easy and controllable approach for fabricating self-rolling tubes that can respond to both magnetic field and light. With the introduction of magnetic nanorods in a hydrogel precursor, a strain gradient is created across the thickness of the formed hydrogel sheet during the photopolymerization process. After the removal of the strain constraint, the nanocomposite sheet rolls up spontaneously. The self-rolling scenario of the sheet can be tuned by varying the sheet geometry and the magnetic nanorod concentration in the hydrogel precursor. The nanocomposite hydrogel tube translates in the presence of a magnetic field and produces heat upon a near-infrared (NIR) light illumination by virtue of the magnetic and photo-thermal properties of the magnetic nanorods. The self-rolling tube either opens up or expands its diameter under NIR light irradiation depending on the number of rolls in the tube. With the use of a thermo-responsive hydrogel material, we demonstrate the magnetically guided motion of the chemical-bearing nanocomposite hydrogel tube and its controlled chemical release through its light-mediated deformation. The approach reported herein is expected to be applicable to other self-rolling polymer-based dry materials, and the nanocomposite hydrogel tube presented in this work may find potential applications in soft robot and controlled release of drug.