journal article·2022-06-01

Novel Glutathione Activated Smart Probe for Photoacoustic Imaging, Photothermal Therapy, and Safe Postsurgery Treatment

Lei Zhang, Wei Zhuang, Ying Yuan, Jingjing Shen, Wenwen Shi, Guan Liu, Weibing Wu, Qing Zhang, Guoqiang Shao, Qunbo Mei, Quli Fan

ACS Applied Materials & Interfaces· Volume 14· Issue 21
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Abstract

Preventing tumor recurrence is the most important target for cancer treatment. However, the current effective and advanced technology relies on the use of near-infrared region (NIR), and the equipment of NIR-I and NIR-II fluorescence imaging technique-based fluorescent-guided surgery is expensive and complicated to operate. Here, we report a safe and effective strategy of an organic-inorganic hybrid gold nanoparticle-based novel smart probe (Au@PDA-ss-PEGm NPs) which is appropriate for photoacoustic imaging (PAI) and plasmonic photothermal therapy (PPTT) of tumors in vivo. After intravenous injection, the probe would be transported to the tumor to penetrate the cellular membrane. Then the disulfide bond on the probe surface would be broken with the help of a high concentration of glutathione in the tumor cell. The remaining Au@PDA NPs would aggregate to form plasmonic nanoclusters and exhibit a notable plasmon coupling enhanced photothermal (PCEPT) effect. Besides, the results further proved its good biosafety and pharmacokinetic characteristics in vivo and, more important, a short time exposure under 808 nm laser after surgical removal of the tumor, which would be effective to prevent tumor recurrence and bring dawn to the high-efficiency treatment of tumors.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Gold and Silver Nanoparticles Synthesis and Applications · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China

Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China

Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Anhui Province Engineering Technology Research Center of Modern Pharmaceutical Preparation, Anhui University of Chinese Medicine, Hefei 230012, China

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · 333 project of Jiangsu province · Primary Research & Development Plan of Jiangsu Province

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