journal article·2021-10-06

Plasmonic Enhancement of Chiroptical Property in Enantiomers Using a Helical Array of Magnetoplasmonic Nanoparticles for Ultrasensitive Chiral Recognition

Juyong Gwak, Se Jeong Park, Hwa Young Choi, Ji Hoon Lee, Ki-Jae Jeong, Dongkyu Lee, Van Tan Tran, Kyung-sun Son, Jaebeom Lee

ACS Applied Materials & Interfaces· Volume 13· Issue 39
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Abstract

Recognition of enantiomeric molecules is essential in pharmaceutical and biomedical applications. In this Article, a novel approach is introduced to monitor chiral molecules via a helical magnetic field ( h B ), where chiral-inactive magnetoplasmonic nanoparticles (MagPlas NPs, Ag@Fe 3 O 4 core–shell NPs) are assembled into helical nanochain structures to be chiral-active. An in-house generator of h B -induced chiral NP assembly, that is, a plasmonic chirality enhancer (PCE), is newly fabricated to enhance the circular dichroism (CD) signals from chiral plasmonic interaction of the helical nanochain assembly with circularly polarized light, reaching a limit of detection (LOD) of 10 –10 M, a 1000-fold enhancement as compared to that of conventional CD spectrometry. These enhancements were successfully observed from enantiomeric molecules, oligomers, polymers, and drugs. Computational simulation studies also proved that total chiroptical properties of helical plasmonic chains could be readily changed by modifying the chiral structure of the analytes. The proposed PCE has the potential to be used as an advanced tool for qualitative and quantitative recognition of chiral materials, enabling further application in pharmaceutical and biomedical sensing and imaging.
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Research context

OpenAlex topics: Metamaterials and Metasurfaces Applications · Plasmonic and Surface Plasmon Research · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomaterials Science, Pusan National University, Miryang 50463, Republic of Korea

Department of Chemistry Engineering and Applied Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea

Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea

Research Institute of Materials Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, People’s Republic of China

Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46279, Republic of Korea

Diagnostics Platform Research Section, Electronics and Telecommunications Research Institute (ETRI), 218 Gajeong-ro, Yuseong-gu, Daejeon 34129, Korea

Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi 12116, Vietnam

Funding

This work was supported by the research fund of Chungnam National University.

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