DataVXACS Applied Materials & InterfacesPaper
journal article·2020-06-17

Ultrasmall T1–T2 Magnetic Resonance Multimodal Imaging Nanoprobes for the Detection of β-amyloid Aggregates in Alzheimer’s Disease Mice

Jing Cai, Peiwei Yi, Yuqing Miao, Jinbo Liu, Yaofang Hu, Qicai Liu, Yanqiu Feng, Huixiong Chen, Li Li

ACS Applied Materials & Interfaces· Volume 12· Issue 24
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Source abstract

Abstract

Alzheimer’s disease (AD) is an irreversible brain disorder and imposes a severe burden upon patients and the public health system. Most research efforts have focused on the search for effective therapeutic drugs, but it is time to pursue efficient early diagnosis based on the reasonable assumption that AD may be easier to prevent than reverse. Recent studies have shown that there are several probes for detecting amyloid-β (Aβ) plaques, one of the neuropathological hallmarks found in AD brain. However, it is still a great challenge for nonradioactive, sensitive detection and location of Aβ plaques by brain imaging with high spatial resolution. Herein, phenothiazine derivative (PZD)-conjugated sub-5 nm ultrasmall ferrite nanoprobes (UFNPs@PEG/PZD) are designed and prepared for efficient T1–T2 magnetic resonance multimodal imaging of Aβ plaques. UFNPs@PEG/PZD not only possess high binding affinity to Aβ plaques but also exhibit excellent properties of r1 and r2 relaxivities. This study thus provides a promising ultrasmall nanoplatform as an Aβ-targeting multimodal imaging probe for the application of early diagnosis of AD.
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Research context

Nanomaterials

OpenAlex topics: Alzheimer's disease research and treatments · Lanthanide and Transition Metal Complexes · Advanced NMR Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Imaging Diagnosis and Interventional Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060 Guangzhou, China

CNRS, UMR8601, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CBNIT, Université Paris Descartes, PRES Sorbonne Paris Cité, UFR, Biomédicale, 75006 Paris, France

School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, 510515 Guangzhou, China

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, 710072 Xi’an, China

Department of Oncology, The Air Force Hospital of Southern Theater Command, 510000 Guangzhou, China

Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Laboratory of Heart Center, Zhujiang Hospital, Southern Medical University, 510515 Guangzhou, China

Funding

State Key Laboratory of Oncology in South China · China Postdoctoral Science Foundation · National Natural Science Foundation of China · State Key Laboratory of Optoelectronic Materials and Technologies

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