journal article·2023-06-14

Biogenic Copper Selenide Nanoparticles for Near-Infrared Photothermal Therapy Application

Xue-Meng Wang, Shaoshan Pan, Lin Chen, Li Wang, Yi-Tao Dai, Tianzhi Luo, Wen-Wei Li

ACS Applied Materials & Interfaces· Volume 15· Issue 23
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Abstract

Near-infrared (NIR) photothermal therapy (PTT) is attractive for cancer treatment but is currently restricted by limited availability and insufficient NIR-II photoactivity of photothermal agents, for which artificial nanomaterials are usually used. Here, we report the first use of biogenic nanomaterials for PTT application. A fine-controlled extracellular biosynthesis of copper selenide nanoparticles (bio-Cu 2– x Se) by Shewanella oneidensis MR-1 was realized. The resulting bio-Cu 2– x Se, with fine sizes (∼35.5 nm) and high product purity, exhibited 76.9% photothermal conversion efficiency under 1064 nm laser irradiation, outperforming almost all the existing counterparts. The protein capping also imparted good biocompatibility to bio-Cu 2– x Se to favor a safe PTT application. The in vivo PTT with injected bio-Cu 2– x Se in mice (without extraction nor further modification) showed 87% tumor ablation without impairing the normal organisms. Our work not only opens a green route to synthesize the NIR-II photothermal nanomaterial but may also lay a basis for the development of bacteria–nanomaterial hybrid therapy technologies.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Quantum Dots Synthesis And Properties · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China

Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou 215123, China

Key Laboratory of Northwest Water Resource, Environment and Ecology, MOE, School of Environmental and Municipal Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230026, China

School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230026, China

Funding

National Natural Science Foundation of China · Science and Technology Program of Suzhou · CAS ?Light of West China? Program

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