journal article·2021-12-08Open access

29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe

Jiwon Kim, Donghyuk Jo, Seung-Hyun Yang, Chan-Gyu Joo, Nicholas Whiting, Shivanand Pudakalakatti, Hyeonglim Seo, Hye Young Son, Sun-Joon Min, Pratip Bhattacharya, Yong-Min Huh, Jeong Hyun Shim, Youngbok Lee

ACS Applied Materials & Interfaces· Volume 13· Issue 48

Abstract

Silicon particles have garnered attention as promising biomedical probes for hyperpolarized 29Si magnetic resonance imaging and spectroscopy. However, due to the limited levels of hyperpolarization for nanosized silicon particles, microscale silicon particles have primarily been the focus of dynamic nuclear polarization (DNP) applications, including in vivo magnetic resonance imaging (MRI). To address these current challenges, we developed a facile synthetic method for partially 29Si-enriched porous silicon nanoparticles (NPs) (160 nm) and examined their usability in hyperpolarized 29Si MRI agents with enhanced signals in spectroscopy and imaging. Hyperpolarization characteristics, such as the build-up constant, the depolarization time (T1), and the overall enhancement of the 29Si-enriched silicon NPs (10 and 15%), were thoroughly investigated and compared with those of a naturally abundant NP (4.7%). During optimal DNP conditions, the 15% enriched silicon NPs showed more than 16-fold higher enhancements─far beyond the enrichment ratio─than the naturally abundant sample, further improving the signal-to-noise ratio in in vivo 29Si MRI. The 29Si-enriched porous silicon NPs used in this work are potentially capable to serve as drug-delivery vehicles in addition to hyperpolarized 29Si in vivo, further enabling their potential future applicability as a theragnostic platform.
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Research context

OpenAlex topics: Advanced NMR Techniques and Applications · Solid-state spectroscopy and crystallography · Advancements in Battery Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bionano Technology, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan 15588, South Korea

Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, South Korea

Interdisciplinary Program in Nanomedical Science and Technology, Nanomedical National Core Research Center, Yonsei University, Seoul 03722, South Korea

Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 03722, South Korea

Department of Physics & Astronomy, Rowan University, Glassboro, New Jersey 08028, United States

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States

Department of Applied Chemistry, Hanyang University, Ansan 15588, South Korea

YUHS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 03722, South Korea

Department of Biochemistry & Molecular Biology, College of Medicine, Yonsei University, Seoul 03722, South Korea

Quantum Magnetic Imaging Team, Korea Research Institute of Standards and Science, Daejeon 34113, South Korea

Funding

National Research Foundation of Korea · Korea Research Institute of Standards and Science

References (36)

Show source-provided references
1. 10.1038/srep1517710.1038/srep15177 ↗
2. 10.1073/pnas.131492811010.1073/pnas.1314928110 ↗
3. 10.1016/s0168-9002(97)00888-710.1016/s0168-9002(97)00888-7 ↗
4. 10.3389/fphys.2016.0007210.3389/fphys.2016.00072 ↗
5. 10.1016/j.jmr.2012.11.01410.1016/j.jmr.2012.11.014 ↗
6. 10.1016/s0720-048x(01)00347-310.1016/s0720-048x(01)00347-3 ↗
7. 10.2533/chimia.2021.33310.2533/chimia.2021.333 ↗
8. 10.1080/05704928.2015.111607810.1080/05704928.2015.1116078 ↗
9. 10.1021/acsami.1c0715610.1021/acsami.1c07156 ↗
10. 10.1002/anie.20191509810.1002/anie.201915098 ↗
11. 10.1117/1.jmi.3.3.03600110.1117/1.jmi.3.3.036001 ↗
12. 10.1073/pnas.173383510010.1073/pnas.1733835100 ↗
13. 10.1016/j.jmr.2011.12.01510.1016/j.jmr.2011.12.015 ↗
14. 10.1021/acs.jpclett.8b0387410.1021/acs.jpclett.8b03874 ↗
15. 10.1002/cmmi.153810.1002/cmmi.1538 ↗
16. 10.1038/nnano.2013.6510.1038/nnano.2013.65 ↗
17. 10.1021/nn305462y10.1021/nn305462y ↗
18. 10.1038/srep1284210.1038/srep12842 ↗
19. 10.2147/nano.2006.1.4.45110.2147/nano.2006.1.4.451 ↗
20. 10.1021/nn700319z10.1021/nn700319z ↗
21. 10.1021/am406061x10.1021/am406061x ↗
22. 10.1021/acsami.7b1453810.1021/acsami.7b14538 ↗
23. 10.1103/physrevb.87.16130610.1103/physrevb.87.161306 ↗
24. 10.1080/05704928.2019.167625510.1080/05704928.2019.1676255 ↗
25. 10.1021/nn900996p10.1021/nn900996p ↗
26. 10.1002/cphc.20180046110.1002/cphc.201800461 ↗
27. 10.1021/acs.jpcc.8b0892610.1021/acs.jpcc.8b08926 ↗
28. 10.1103/PhysRevLett.100.12760110.1103/PhysRevLett.100.127601 ↗
29. 10.1021/acs.jpcc.8b0091110.1021/acs.jpcc.8b00911 ↗
30. 10.1002/anie.20170903910.1002/anie.201709039 ↗
31. 10.1016/j.jnoncrysol.2005.05.00210.1016/j.jnoncrysol.2005.05.002 ↗
32. 10.1016/j.ssnmr.2014.12.00710.1016/j.ssnmr.2014.12.007 ↗
33. 10.1002/wnan.172210.1002/wnan.1722 ↗
34. 10.1016/0021-9797(68)90272-510.1016/0021-9797(68)90272-5 ↗
35. 10.1039/c4cc10008e10.1039/c4cc10008e ↗
36. 10.1038/srep2288810.1038/srep22888 ↗