journal article·2021-10-27

Super-Assembled Periodic Mesoporous Organosilica Frameworks for Real-Time Hypoxia-Triggered Drug Release and Monitoring

Yingnan Liu, Lei Xie, Meng Gao, Runhao Zhang, Jingchen Gao, Jiangdong Sun, Qingdong Chai, Tong Wu, Kang Liang, Pu Chen, Qi Wan, Biao Kong

ACS Applied Materials & Interfaces· Volume 13· Issue 42
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Abstract

Hypoxia, induced by inadequate oxygen supply, is a key indication of various major illnesses, which necessitates the need to develop new nanoprobes capable of sensing hypoxia environments for the targeted system monitoring and drug delivery. Herein, we report a hypoxia-responsive, periodic mesoporous organosilica (PMO) nanocarrier for repairing hypoxia damage. β-cyclodextrin (β-CD) capped azobenzene functionalization on the PMO surface could be effectively cleaved by azoreductase under a hypoxia environment. Moreover, the nanosystem is equipped with fluorescence resonance energy transfer (FRET) pair (tetrastyrene derivative (TPE) covalently attached to the PMO framework as the donor and Rhodamine B (RhB) in the mesopores as the receptor) for intracellular visualization and tracking of drug release in real-time. The design of intelligent nanocarriers capable of simultaneous reporting and treating of hypoxia conditions highlights a great potential in the biomedical domain.
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Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Mesoporous Materials and Catalysis · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Advanced Cross-field Science, College of Life Science, Qingdao University, 308 Ningxia Street, Qingdao 266071, P. R. China

Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P. R. China

National Supercomputer Research Center of Advanced Materials, Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, P. R. China

Institute of Neuroregeneration & Neurorehabilitation, Department of Pathophysiology, Qingdao University, 308 Ningxia Street, Qingdao 266071, P. R. China

School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, New South Wales 2052, Australia

Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada

Funding

Natural Science Foundation of Shanghai · Ministry of Science and Technology of the People's Republic of China · Shanghai Municipal Education Commission · Shanghai Key Laboratory of Molecular Imaging · National Natural Science Foundation of China

References (45)

Show source-provided references
1. 10.1073/pnas.131834511010.1073/pnas.1318345110 ↗
2. 10.1183/09031936.0011120810.1183/09031936.00111208 ↗
3. 10.1021/acs.nanolett.9b0497410.1021/acs.nanolett.9b04974 ↗
4. 10.1016/j.lfs.2019.02.05810.1016/j.lfs.2019.02.058 ↗
5. 10.1016/j.nano.2018.05.01410.1016/j.nano.2018.05.014 ↗
6. 10.1002/anie.20201039110.1002/anie.202010391 ↗
7. 10.1016/j.msec.2020.11131410.1016/j.msec.2020.111314 ↗
8. 10.1021/ja991665810.1021/ja9916658 ↗
9. 10.1038/4722910.1038/47229 ↗
10. 10.1016/j.biomaterials.2018.05.02510.1016/j.biomaterials.2018.05.025 ↗
11. 10.1021/jacs.7b1069410.1021/jacs.7b10694 ↗
12. 10.1039/C9TA01281H10.1039/C9TA01281H ↗
13. 10.1021/acs.analchem.0c0422610.1021/acs.analchem.0c04226 ↗
14. 10.1007/s12274-020-2736-610.1007/s12274-020-2736-6 ↗
15. 10.1021/acsami.8b0906910.1021/acsami.8b09069 ↗
16. 10.1016/j.biomaterials.2017.07.03010.1016/j.biomaterials.2017.07.030 ↗
17. 10.1021/acs.jpcc.6b0183710.1021/acs.jpcc.6b01837 ↗
18. 10.1039/C5SC02044A10.1039/C5SC02044A ↗
19. 10.1016/j.actbio.2018.12.01210.1016/j.actbio.2018.12.012 ↗
20. 10.1021/acsami.6b0488510.1021/acsami.6b04885 ↗
21. 10.1021/acs.chemrev.5b0045610.1021/acs.chemrev.5b00456 ↗
22. 10.1002/cphc.20100066410.1002/cphc.201000664 ↗
23. 10.1021/acsami.9b0493810.1021/acsami.9b04938 ↗
24. 10.1016/j.jconrel.2020.04.04610.1016/j.jconrel.2020.04.046 ↗
25. 10.1038/nnano.2014.27410.1038/nnano.2014.274 ↗
26. 10.1021/ac501028m10.1021/ac501028m ↗
27. 10.3390/ijms13121659810.3390/ijms131216598 ↗
28. 10.1038/nchem.240510.1038/nchem.2405 ↗
29. 10.1016/j.neuint.2016.04.00110.1016/j.neuint.2016.04.001 ↗
30. 10.1038/sj.cdd.440087710.1038/sj.cdd.4400877 ↗
31. 10.1016/j.neuint.2012.07.00510.1016/j.neuint.2012.07.005 ↗
32. 10.1021/acsami.9b0414210.1021/acsami.9b04142 ↗
33. 10.1039/D0AN00841A10.1039/D0AN00841A ↗
34. 10.1039/C9AN01671F10.1039/C9AN01671F ↗
35. 10.1021/ja105937q10.1021/ja105937q ↗
36. 10.1021/ma801202f10.1021/ma801202f ↗
37. 10.1002/anie.20200801810.1002/anie.202008018 ↗
38. 10.1016/j.tibs.2014.02.00410.1016/j.tibs.2014.02.004 ↗
39. 10.1021/am302492e10.1021/am302492e ↗
40. 10.1016/j.biomaterials.2016.11.02310.1016/j.biomaterials.2016.11.023 ↗
41. 10.1021/acsami.8b0649110.1021/acsami.8b06491 ↗
42. 10.1021/acs.analchem.9b0527810.1021/acs.analchem.9b05278 ↗
43. 10.1021/acs.biomac.7b0140910.1021/acs.biomac.7b01409 ↗
44. 10.1021/acsami.8b0012910.1021/acsami.8b00129 ↗
45. 10.1021/acsnano.8b0378810.1021/acsnano.8b03788 ↗