Conjugated Polyelectrolyte Nanoparticles for Apoptotic Cell Imaging

Yu Liu; Pan Wu; Jianhua Jiang; Jiatao Wu; Yan Chen; Ying Tan; Chunyan Tan; Yuyang Jiang

doi:10.1021/acsami.6b09347

journal article·2016-08-31

Conjugated Polyelectrolyte Nanoparticles for Apoptotic Cell Imaging

Yu Liu, Pan Wu, Jianhua Jiang, Jiatao Wu, Yan Chen, Ying Tan, Chunyan Tan, Yuyang Jiang

ACS Applied Materials & Interfaces· Volume 8· Issue 34

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Source abstract

Abstract

Three anionic conjugated polyelectrolytes (CPEs) with poly(p-phenylene ethynylene thiophene) backbones were designed and synthesized, among which PPET3-CO2Na showed greater molar extinction coefficient with red-shifted bands in both absorption and emission spectra compared to the well-studied PPE-CO2Na polymer. PPET3-CO2Na was thus chosen to construct CPE-based nanoparticles (CPNs) with cationic octaarginine (R8) peptide through electrostatic-interaction-induced self-assembly. Due to plasma membrane permeabilization and mitochondrial outer membrane permeabilization (MOMP) in early apoptotic cells, PPET3/R8 CPNs demonstrated excellent colocalization with MitoTracker Red in apoptotic cells instead of normal cells, which had potential application in cell imaging for early apoptosis recognition.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Luminescence and Fluorescent Materials · Dendrimers and Hyperbranched Polymers · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China

The Ministry-Province Jointly Constructed Base for State Key Lab - Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China

Shenzhen Technology and Engineering Laboratory for Personalized Cancer Diagnostics and Therapeutics, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, P. R. China

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, P. R. China

Funding

National Natural Science Foundation of China · Shenzhen Municipal Development and Reform Commission · Shenzhen Municipal Government

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