DataVXACS Applied Materials & InterfacesPaper
journal article·2023-06-07

SiC/Graphene Film by Laser CVD as an Implantable Sensor Material for Dopamine Detection

Cuicui Li, Yilun Cai, Jinrong Hu, Jiawei Liu, Honglian Dai, Qingfang Xu, Chitengfei Zhang, Xian Zhang, Kai Liu, Marina L. Kosinova, Takashi Goto, Rong Tu, Song Zhang

ACS Applied Materials & Interfaces· Volume 15· Issue 22
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Source abstract

Abstract

Implantable electrochemical sensor holds great promise in the real-time monitoring of dopamine (DA) to regulate body function. However, the real application of these sensors is limited by the weak current signal of DA in the human body and the poor compatibility of the on-chip microelectronic devices. In this work, a SiC/graphene composite film was fabricated using laser chemical vapor deposition (LCVD) and employed as a DA sensor. The graphene in the porous nanoforest-like SiC framework offered efficient channels for electronic transmission, leading to an enhanced electron transfer rate and consequently an increased current response for DA detection. The three-dimensional (3D) porous network also facilitated the exposure of more catalytic active sites toward DA oxidation. Besides, the wide distribution of graphene in the nanoforest-like SiC films reduced the interfacial resistance of the charge transfer. The SiC/graphene composite film exhibited excellent electrocatalytic activity toward DA oxidation with a low detection limit of 0.11 μM and a high sensitivity of 0.86 μA·μM –1 ·cm –2 . The film electrode also showed a wide linear response for DA in 0.5–78 μM, along with good selectivity, repeatability, and reproducibility. Furthermore, the cell counting kit-8 (CCK-8) and live–dead assays revealed that the film is also biocompatible for biomedical applications. Therefore, the nanoforest-like SiC/graphene composite film via the CVD process enables a promising candidate for an integrated miniature DA biosensor with high detection performance.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterialsCompositesCatalysis & surfacesMaterials processing

OpenAlex topics: Electrochemical sensors and biosensors · Supercapacitor Materials and Fabrication · Graphene research and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China

Hospital of Wuhan University of Technology, Wuhan University of Technology, Wuhan 430070, China

School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430070, China

Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China

Wuhan University of Technology Advanced Engineering Technology Research Institute of Zhongshan City, Zhongshan 528400, China

Nikolaev Institute of Inorganic Chemistry, Russian Academy of Sciences Siberian Branch, Novosibirsk 630090, Russia

New Industry Creation Hatchery Center, Tohoku University, Sendai 980-8579, Japan

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · Special Project for Research and Development in Key areas of Guangdong Province · Basic and Applied Basic Research Foundation of Guangdong Province · Natural Science Foundation of Fujian Province · Wuhan University of Technology · National Natural Science Foundation of China · Higher Education Discipline Innovation Project · Chaozhou Science and Technology Project · Technological Innovation of Hubei Province · Major Science and Technology Project in Zhongshan City, Guangdong Province · Hanjiang Laboratory

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