DataVXACS Applied Materials & InterfacesPaper
journal article·2022-07-06

Exogenously Triggered Nanozyme for Real-Time Magnetic Resonance Imaging-Guided Synergistic Cascade Tumor Therapy

Hongji Liu, Junjun Wang, Chao Song, Ke Zhou, Biao Yu, Jialiang Jiang, Junchao Qian, Xin Zhang, Hui Wang

ACS Applied Materials & Interfaces· Volume 14· Issue 26
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Source abstract

Abstract

The uncontrolled treatment process and high concentration of intracellular glutathione compromise the therapeutic efficacies of chemodynamic therapy (CDT). Here, iron oxide nanocrystals embedded in N-doped carbon nanosheets (IONCNs) are designed as a near-infrared light-triggered nanozyme for synergistic cascade tumor therapy. The IONCNs can absorb and convert 980 nm light to local heat, which induces the dissolution of iron oxide for generating Fe2+/Fe3+ in a weak acid environment, apart from thermal ablation of cancer cells. The formed Fe2+ takes on the active site for the Fenton reaction. The formed Fe3+ acts as glutathione peroxidase to magnify oxidative stress, improving the antitumor performance. The IONCNs can be used to visually track the treatment process via magnetic resonance imaging. Such IONCNs demonstrate great potential as an exogenously triggered nanozyme via an integrated cascade reaction for imaging-guided synergistic cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China

University of Science and Technology of China, Hefei 230026, Anhui, P. R. China

The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, China

Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, China

Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · High Magnetic Field Laboratory of Anhui Province

References (60)

Show source-provided references
1. 10.1038/nnano.2007.26010.1038/nnano.2007.260 ↗
2. 10.1039/C8CS00718G10.1039/C8CS00718G ↗
3. 10.1002/adma.20180536810.1002/adma.201805368 ↗
4. 10.1002/adma.20200356310.1002/adma.202003563 ↗
5. 10.1093/nsr/nwaa16010.1093/nsr/nwaa160 ↗
6. 10.1002/adma.20210047210.1002/adma.202100472 ↗
7. 10.1002/anie.20151003110.1002/anie.201510031 ↗
8. 10.1002/adma.20190177810.1002/adma.201901778 ↗
9. 10.1021/acsabm.0c0112710.1021/acsabm.0c01127 ↗
10. 10.1002/advs.20200281610.1002/advs.202002816 ↗
11. 10.1002/advs.20200027210.1002/advs.202000272 ↗
12. 10.1021/acsnano.8b0620110.1021/acsnano.8b06201 ↗
13. 10.1002/anie.20210086410.1002/anie.202100864 ↗
14. 10.1002/smll.20210742210.1002/smll.202107422 ↗
15. 10.1002/adfm.20200275310.1002/adfm.202002753 ↗
16. 10.1002/adma.20200243910.1002/adma.202002439 ↗
17. 10.1021/acsnano.0c0629010.1021/acsnano.0c06290 ↗
18. 10.1021/acs.chemrev.0c0097710.1021/acs.chemrev.0c00977 ↗
19. 10.1016/j.ccell.2017.11.01510.1016/j.ccell.2017.11.015 ↗
20. 10.1038/s41467-018-03617-x10.1038/s41467-018-03617-x ↗
21. 10.1038/s41467-018-03903-810.1038/s41467-018-03903-8 ↗
22. 10.1002/adfm.20190141710.1002/adfm.201901417 ↗
23. 10.1002/adma.20190073010.1002/adma.201900730 ↗
24. 10.1002/adfm.20200609810.1002/adfm.202006098 ↗
25. 10.1039/c3cs35486e10.1039/c3cs35486e ↗
26. 10.1039/D0MH01225D10.1039/D0MH01225D ↗
27. 10.1021/acsnano.1c0107710.1021/acsnano.1c01077 ↗
28. 10.1021/acsnano.8b0870210.1021/acsnano.8b08702 ↗
29. 10.1016/j.cej.2019.12360910.1016/j.cej.2019.123609 ↗
30. 10.1039/C8CS00342D10.1039/C8CS00342D ↗
31. 10.1002/adma.20160201210.1002/adma.201602012 ↗
32. 10.1039/C8CS00001H10.1039/C8CS00001H ↗
33. 10.1016/j.biomaterials.2019.11970010.1016/j.biomaterials.2019.119700 ↗
34. 10.1021/acsnano.9b0128110.1021/acsnano.9b01281 ↗
35. 10.1039/D0GC00845A10.1039/D0GC00845A ↗
36. 10.1021/nn401717910.1021/nn4017179 ↗
37. 10.1002/anie.20070169410.1002/anie.200701694 ↗
38. 10.1002/adfm.20200919710.1002/adfm.202009197 ↗
39. 10.1016/j.isci.2019.08.01910.1016/j.isci.2019.08.019 ↗
40. 10.1002/smll.20210352810.1002/smll.202103528 ↗
41. 10.1002/anie.20201149510.1002/anie.202011495 ↗
42. 10.1002/adma.20200003810.1002/adma.202000038 ↗
43. 10.1021/jacs.5b1275810.1021/jacs.5b12758 ↗
44. 10.1002/aenm.20170247610.1002/aenm.201702476 ↗
45. 10.1016/j.chempr.2017.10.01310.1016/j.chempr.2017.10.013 ↗
46. 10.1016/j.chempr.2017.05.02110.1016/j.chempr.2017.05.021 ↗
47. 10.1016/j.cej.2020.12455510.1016/j.cej.2020.124555 ↗
48. 10.1002/anie.20210333610.1002/anie.202103336 ↗
49. 10.1002/aenm.20180095510.1002/aenm.201800955 ↗
50. 10.1016/j.isci.2021.10254710.1016/j.isci.2021.102547 ↗
51. 10.1021/acs.est.6b0471610.1021/acs.est.6b04716 ↗
52. 10.1038/nnano.2015.34210.1038/nnano.2015.342 ↗
53. 10.1016/j.biomaterials.2017.06.02110.1016/j.biomaterials.2017.06.021 ↗
54. 10.1016/j.apmt.2018.11.01110.1016/j.apmt.2018.11.011 ↗
55. 10.1021/acs.langmuir.9b0300110.1021/acs.langmuir.9b03001 ↗
56. 10.1021/acsnano.7b0687010.1021/acsnano.7b06870 ↗
57. 10.1016/j.carbon.2018.04.05010.1016/j.carbon.2018.04.050 ↗
58. 10.1021/acs.nanolett.0c0312710.1021/acs.nanolett.0c03127 ↗
59. 10.1002/adma.20210115510.1002/adma.202101155 ↗
60. 10.1021/acsnano.0c0514310.1021/acsnano.0c05143 ↗