journal article·2022-06-22

Multifunction in One Nanoparticle for Anticancer Therapy: Bowl-Shaped Au@PDA Yolk–Shell NPs

Xin Ding, Tianyu Wang, Shiwei Bai, Yunfeng Wan, Shuai Zhu, Tao Li, Na Peng, Tao Qiu, Yi Liu

ACS Applied Materials & Interfaces· Volume 14· Issue 24
Publisher page

Abstract

Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@polydopamine yolk–shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 μg mg–1). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong near-infrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province & Institute of Advanced Technology and Nanomaterials, College of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, P. R. China

Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan 430060, P. R. China

Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P. R. China

State Key Laboratory of Separation Membrane and Membrane Process & Tianjin Key Laboratory of Green Chemical Technology and Process Engineering, School of Chemistry, Tiangong University, Tianjin 300387, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China

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