journal article·2021-06-23

1T-Phase Dirac Semimetal PdTe2 Nanoparticles for Efficient Photothermal Therapy in the NIR-II Biowindow

Jingjing Luo, Mingjian Fan, Liwei Xiong, Qiaoyan Hao, Mengna Jiang, Qianjun He, Chenliang Su

ACS Applied Materials & Interfaces· Volume 13· Issue 24
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Abstract

1T-phase transition-metal dichalcogenides (TMDs) nanomaterials are one type of emerging and promising near-infrared II (NIR-II) photothermal agents (PTAs) derived from their distinct metallic electronic structure, but it is still challenging to synthesize these nanomaterials. Herein, PdTe2 nanoparticles (PTNs) with a 1T crystal symmetry and around 50 nm in size are prepared by an electrochemical exfoliation method, and the corresponding photothermal performances irradiated under a NIR-II laser have been explored. The encapsulation of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG) endows PTNs with water solubility, enhanced photothermal stability, and high biocompatibility. Notably, PTN/DSPE-PEG displays a potent absorbance through the NIR-II zone and considerable photothermal conversion efficiency, which is up to 68% when irradiated with a 1060 nm laser. With these unique photothermal properties, excellent in vitro and in vivo tumor inhibition effects of PTN/DSPE-PEG have been achieved under the irradiation of a NIR-II (1060 nm) laser without visible toxicity to normal tissues, suggesting that it is an efficient NIR-II photothermal nanoagent.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · 2D Materials and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province, Institute of Microscale Optoelectronics, Shenzhen University, No. 3688 Nanhai Avenue, Shenzhen 518060, China

School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Shenzhen 518060, China

Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology, Wuhan 430205, China

Funding

National Natural Science Foundation of China · Shenzhen Peacock Plan · SZU Top Ranking Project · Special Funds for the Development of Strategic Emerging Industries in Shenzhen · Guangdong Special Support Program, Pengcheng Scholar Program, Shenzhen Basic Research Program · Hubei Key Laboratory of Plasma Chemistry and Advanced Materials for the Open Fund

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