DataVXACS Applied Materials & InterfacesPaper
journal article·2017-03-08

Assessing the Biocidal Activity and Investigating the Mechanism of Oligo-p-phenylene-ethynylenes

Jing Wang, Liangang Zhuo, Wei Liao, Xia Yang, Zhenghua Tang, Yue Chen, Shunzhong Luo, Zhijun Zhou

ACS Applied Materials & Interfaces· Volume 9· Issue 9
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Source abstract

Abstract

A number of oligo-p-phenylene-ethynylenes (OPEs) have exhibited excellent biocidal activity against both Gram-negative and Gram-positive bacteria. Although cell death may occur in the dark, these biocidal compounds are far more effective in the light as a result of their abilities to generate cell-damaging reactive oxygen species. In this study, the interactions of four OPEs with Escherichia coli and Staphylococcus aureus have been investigated. Compared to the OPEs with quaternary ammonium salts (Q-OPE), the OPEs with tertiary ammonium (T-OPE) effectively kill many more bacterial cells under light irradiation, presumably by severe perturbations of the bacterial cell wall and cytoplasmic membrane. According to the findings from this study, such intriguing light-induced antibacterial behavior is probably attributed to the combination of bacterial membrane disruption and the interfacial or intracellular generation of singlet oxygen or other ROS. Singlet oxygen was proved to be formed from irradiation of the OPEs, whereas the varying cell membrane perturbation abilities of OPEs enhance antibacterial activity.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Antimicrobial agents and applications · Marine Biology and Environmental Chemistry · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 64 Mianshan Road, Mianyang, Sichuan 621900, People’s Republic of China

New Energy Research Institute, School of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Centre, Guangzhou 510006, People’s Republic of China

Provincial Key Laboratory of Atmospheric Environment and Pollution Control, Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal, South China University of Technology, Guangzhou Higher Education Mega Centre, Guangzhou 510006, People’s Republic of China

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China

Funding

National Natural Science Foundation of China · China Academy of Engineering Physics · Guangdong Province · Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics

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