journal article·2021Open access

peri -Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm

Joscha Mulorz, Mahdis Shayan, Caroline Hu, Cynthia Alcazar, Alex H. P. Chan, Mason Briggs, Yan Wen, Ankita P. Walvekar, Anand K. Ramasubramanian, Joshua M. Spin, Bertha Chen, Philip S. Tsao, Ngan F. Huang

Biomaterials Science· Volume 9· Issue 20

Abstract

-adventitia on day 7 following AAA induction using pancreatic porcine elastase infusion. Ultrasound imaging revealed that SMC-seeded scaffolds significantly reduced the aortic diameter by 28 days, compared to scaffolds seeded with iPSC-SMPs or without cells (acellular scaffold), respectively. Bioluminescence imaging demonstrated that both cell-seeded scaffold groups had cellular localization to the aneurysm but a decline in survival with time. Histological analysis revealed that both cell-seeded scaffold groups had more SMC retention and less macrophage invasion into the medial layer of AAA lesions, when compared to the acellular scaffold treatment group. Our data suggest that scaffold-based SMC delivery is feasible and may constitute a platform for cell-based AAA therapy.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Aortic aneurysm repair treatments · Infectious Aortic and Vascular Conditions · Aortic Disease and Treatment Approaches

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA

Department of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany

Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA

Department Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA

Stanford University School of Medicine, Department of Obstetrics and Gynecology, Stanford, CA, USA

Department of Chemical and Materials Engineering, San Jose State University, San Jose, CA, USA

Funding

Deutsche Forschungsgemeinschaft · Tobacco-Related Disease Research Program · California Institute for Regenerative Medicine · U.S. Department of Veterans Affairs · Center for Scientific Review · American Heart Association · National Science Foundation

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