DataVXACS Applied Materials & InterfacesPaper
journal article·2018-08-08Open access

Hybrid Mesoporous Nanocarriers Act by Processing Logic Tasks: Toward the Design of Nanobots Capable of Reading Information from the Environment

Antoni Llopis-Lorente, Beatriz de Luis, Alba García-Fernández, Sandra Jimenez-Falcao, Mar Orzáez, Félix Sancenón, Reynaldo Villalonga, Ramón Martínez-Máñez

ACS Applied Materials & Interfaces· Volume 10· Issue 31
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Source abstract

Abstract

Here, we present the design of smart nanodevices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au–mesoporous silica (MS) nanoparticles functionalized with the enzyme glucose dehydrogenase (GDH) on the Au surface and with supramolecular nanovalves as caps on the MS surface, which is loaded with a cargo (dye or drug). The nanodevice acts as an AND logic gate and reads information from the solution (presence of glucose and nicotinamide adenine dinucleotide (NAD+)), which results in cargo release. We show the possibility of coimmobilizing GDH and the enzyme urease on nanoparticles to mimic an INHIBIT logic gate, in which the AND gate is switched off by the presence of urea. We also show that such nanodevices can deliver cytotoxic drugs in cancer cells by recognizing intracellular NAD+ and the presence of glucose.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis · Electrochemical sensors and biosensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Instituto de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universidad Politécnica de Valencia-Universidad de Valencia, 46022 València, Spain

Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain

CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012 Valencia, Spain

Nanosensors & Nanomachines Group, Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain

Funding

Generalitat Valenciana · ?la Caixa? Foundation · Secretar?a de Estado de Investigaci?n, Desarrollo e Innovaci?n · Consejer?a de Educaci?n, Juventud y Deporte, Comunidad de Madrid

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