DataVXACS Applied Materials & InterfacesPaper
journal article·2023-11-29

Core–Shell Au@Pd Bimetallic Nanozyme Mediated Mild Photothermal Therapy through Reactive Oxygen Species-Regulating Tumor Thermoresistance

Yaru Zhang, Zhaocong Zheng, Zhankun Chen, Xiaozhao Wang, Wei Chen, Zhimin Gao, Jiamin Luo, Chen Lin, Wenyu Xie, Yuchi Wan, Meiling Tan, Donglian Liu, Zhiyao Hou

ACS Applied Materials & Interfaces· Volume 15· Issue 47
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Source abstract

Abstract

Mild photothermal therapy (mPTT), which circumvents the limitations of conventional photothermal therapy, is emerging and exhibits remarkable potential in clinical applications. Nevertheless, mPTT is not able to efficiently eradicate tumors because its therapeutic efficacy is dramatically diminished by stress-induced heat shock proteins (HSP). Herein, a core-shell structured Au@Pd (AP) bimetallic nanozyme was fabricated for reactive oxygen species (ROS) augmentation-induced mPTT. The nanocatalytic AP nanozymes with photothermal conversion performance harbor multienzymatic (catalase, oxidase, and peroxidase) activities to induce ROS storm formation. The generated ROS could suppress the heat-defense response of tumor cells by cleaving HSP. Overall, our work highlights a ROS-regulating strategy to counteract hyperthermia-associated resistance in mPTT.
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Research context

Nanomaterials

OpenAlex topics: Reflective Practices in Education · Education Systems and Policy · Evaluation of Teaching Practices

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan 511518, P. R. China

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China

School of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, P. R. China

Funding

Basic and Applied Basic Research Foundation of Guangdong Province · Guangzhou Municipal Science and Technology Program key projects · Department of Education of Guangdong Province · National Natural Science Foundation of China · Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital

References (33)

Show source-provided references
1. 10.1002/anie.20191147710.1002/anie.201911477 ↗
2. 10.1002/adma.20230233510.1002/adma.202302335 ↗
3. 10.1021/acsami.3c0185810.1021/acsami.3c01858 ↗
4. 10.1002/adhm.20200180610.1002/adhm.202001806 ↗
5. 10.1021/jacs.1c1306710.1021/jacs.1c13067 ↗
6. 10.1002/smll.20190050110.1002/smll.201900501 ↗
7. 10.1002/adfm.20221313410.1002/adfm.202213134 ↗
8. 10.1002/anie.20210192410.1002/anie.202101924 ↗
9. 10.1038/s41467-019-12771-910.1038/s41467-019-12771-9 ↗
10. 10.1002/adfm.20180463410.1002/adfm.201804634 ↗
11. 10.1002/adma.20170358810.1002/adma.201703588 ↗
12. 10.1016/j.bioactmat.2021.08.01810.1016/j.bioactmat.2021.08.018 ↗
13. 10.1016/j.jconrel.2017.01.01310.1016/j.jconrel.2017.01.013 ↗
14. 10.1016/s1470-2045(13)70169-410.1016/s1470-2045(13)70169-4 ↗
15. 10.1016/j.ajps.2021.10.00110.1016/j.ajps.2021.10.001 ↗
16. 10.1039/D0NR03931D10.1039/D0NR03931D ↗
17. 10.1016/j.actbio.2021.08.01510.1016/j.actbio.2021.08.015 ↗
18. 10.1002/adma.20200243910.1002/adma.202002439 ↗
19. 10.1002/adma.20221046410.1002/adma.202210464 ↗
20. 10.1002/adma.20140510510.1002/adma.201405105 ↗
21. 10.1002/smll.20180185110.1002/smll.201801851 ↗
22. 10.1021/acs.nanolett.9b0225310.1021/acs.nanolett.9b02253 ↗
23. 10.1002/adhm.20220080910.1002/adhm.202200809 ↗
24. 10.1021/acsami.9b1512310.1021/acsami.9b15123 ↗
25. 10.1016/j.nanoen.2016.02.05910.1016/j.nanoen.2016.02.059 ↗
26. 10.1126/science.111580010.1126/science.1115800 ↗
27. 10.1021/acs.chemrev.8b0067210.1021/acs.chemrev.8b00672 ↗
28. 10.1002/adma.20210699610.1002/adma.202106996 ↗
29. 10.1007/s40820-021-00674-810.1007/s40820-021-00674-8 ↗
30. 10.1021/acsami.2c0395210.1021/acsami.2c03952 ↗
31. 10.1039/d0nr06270g10.1039/d0nr06270g ↗
32. 10.1016/j.ejpb.2007.06.01010.1016/j.ejpb.2007.06.010 ↗
33. 10.1002/anie.20180566410.1002/anie.201805664 ↗