Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T₁-Weighted Contrast-Enhanced Brain Imaging

Ruixue Wei; Kun Liu; Ke Zhang; Yifan Fan; Hongyu Lin; Jinhao Gao

doi:10.1021/acsami.1c20617

journal article·2022-01-26

Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T₁-Weighted Contrast-Enhanced Brain Imaging

Ruixue Wei, Kun Liu, Ke Zhang, Yifan Fan, Hongyu Lin, Jinhao Gao

ACS Applied Materials & Interfaces· Volume 14· Issue 3

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Abstract

Manganese oxide nanoparticles (NPs) have attracted increasing attention recently as contrast agents (CAs) for magnetic resonance imaging (MRI). However, the clinical translation and popularization of conventional MnO NPs are hampered by their relatively poor imaging performance. Herein, we report the construction of ultrasmall MnO NPs (USMnO) via a one-pot synthetic approach that show a much better capability of T1-weighted contrast enhancement for MRI (r1 = 15.6 ± 0.4 mM–1 s–1 at 0.5 T) than MnCl2 and conventional large-sized MnO NPs (MnO-22). These USMnO are further coated with zwitterionic dopamine sulfonate (ZDS) molecules, which improves their biocompatibility and prevents nonspecific binding of serum albumins. Interestingly, USMnO@ZDS are capable of passing through the blood–brain barrier (BBB), which enables the acquisition of clear images showing brain anatomic structures with T1-weighted contrast-enhanced MRI. Therefore, our USMnO@ZDS could be used as a promising MRI CA for the flexible and accurate diagnosis of brain diseases, which is also instructive for the construction of manganese-based CA with a high MRI performance.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

Department of Interventional Medicine, Center for Interventional Medicine, Guangdong Provincial Engineering Research Center of Molecular Imaging, and Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Fujian Province of China · Youth Innovation Funding Program of Xiamen City

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