Nonionic and Water-Soluble Poly(d/l-serine) as a Promising Biomedical Polymer for Cryopreservation

Yuling Sun; Jie Liu; Zhibo Li; Jianjun Wang; Yanbin Huang

doi:10.1021/acsami.0c22308

journal article·2021-04-28

Nonionic and Water-Soluble Poly(d/l-serine) as a Promising Biomedical Polymer for Cryopreservation

Yuling Sun, Jie Liu, Zhibo Li, Jianjun Wang, Yanbin Huang

ACS Applied Materials & Interfaces· Volume 13· Issue 16

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Source abstract

Abstract

Water-soluble, biodegradable, nonionic, and biocompatible polymers with multiple functional groups are highly desired for biomedical applications. Here, we report that water-soluble nonionic poly(d/l-serine) is chirality-controllable, biodegradation-controllable, and non-cytotoxic. Hence, it can be a highly sought-after alternative to the widely used poly(ethylene glycol), with an additional advantage of having multiple hydroxyl groups for further functionalization. As one example of its biomedical applications, poly(d/l-serine) demonstrated an obvious cryoprotective effect on the red blood cells. The usage of poly(d/l-serine) in the cryopreservation field would be of great promise to resolve the difficulties in separating cryoprotectants due to toxicity.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Biomaterials

OpenAlex topics: Polyamine Metabolism and Applications · Biopolymer Synthesis and Applications · biodegradable polymer synthesis and properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Max Planck Institute for Polymer Research, Mainz 55128, Germany

School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Chinese Academy of Sciences

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