DataVXACS Applied Materials & InterfacesPaper
journal article·2017-10-18

Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release

Yongbeom Seo, Jiayu Leong, Jye Yng Teo, Jennifer W. Mitchell, Martha U. Gillette, Bumsoo Han, Jonghwi Lee, Hyunjoon Kong

ACS Applied Materials & Interfaces· Volume 9· Issue 41
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Source abstract

Abstract

Overproduced reactive oxygen species (ROS) are closely related to various health problems including inflammation, infection, and cancer. Abnormally high ROS levels can cause serious oxidative damage to biomolecules, cells, and tissues. A series of nano- or microsized particles has been developed to reduce the oxidative stress level by delivering antioxidant drugs. However, most systems are often plagued by slow molecular discharge, driven by diffusion. Herein, this study demonstrates the polymeric particles whose internal pressure can increase upon exposure to H 2 O 2, one of the ROS, and in turn, discharge antioxidants actively. The on-demand pressurized particles are assembled by simultaneously encapsulating water-dispersible manganese oxide (MnO 2 ) nanosheets and green tea derived epigallocatechin gallate (EGCG) molecules into a poly(lactic- co -glycolic acid) (PLGA) spherical shell. In the presence of H 2 O 2, the MnO 2 nanosheets in the PLGA particle generate oxygen gas by decomposing H 2 O 2 and increase the internal pressure. The pressurized PLGA particles release antioxidative EGCG actively and, in turn, protect vascular and brain tissues from oxidative damage more effectively than the particles without MnO 2 nanosheets. This H 2 O 2 responsive, self-pressurizing particle system would be useful to deliver a wide array of molecular cargos in response to the oxidation level.
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Research context

PolymersNanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore

Department of Cell and Developmental Biology, Neuroscience Program, Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

Department of Cell and Developmental Biology, Department of Bioengineering, Neuroscience Program, Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

School of Mechanical Engineering, Birck Nanotechnology Center, Purdue Center for Cancer Research, Purdue University, 585 Purdue Mall, West Lafayette, Indiana 47907, United States

Department of Chemical Engineering and Materials Science, Chung-Ang University, Seoul 156-756, South Korea

Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Institute for Genomic Biology, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

Funding

Division of Biological Infrastructure · Agency for Science, Technology and Research · National Heart, Lung, and Blood Institute · U.S. Department of Defense · National Institute of Mental Health · Division of Chemical, Bioengineering, Environmental, and Transport Systems

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