journal article·2022-11-09Open access

Upconversion Nanoparticle-Based Cell Membrane-Coated cRGD Peptide Bioorthogonally Labeled Nanoplatform for Glioblastoma Treatment

Jingxin Mo, Xianjue Chen, Meiying Li, Wenxu Liu, Wei Zhao, Lee Yong Lim, Richard D. Tilley, J. Justin Gooding, Qinghua Li

ACS Applied Materials & Interfaces· Volume 14· Issue 44

Abstract

Glioblastoma is hard to be eradicated partly because of the obstructive blood–brain barrier (BBB) and the dynamic autophagy activities of glioblastoma. Here, hydroxychloroquine (HDX)-loaded yolk–shell upconversion nanoparticle (UCNP)@Zn0.5Cd0.5S nanoparticle coating with the cyclic Arg-Gly-Asp (cRGD)-grafted glioblastoma cell membrane for near-infrared (NIR)-triggered treatment of glioblastoma is prepared for the first time. UCNPs@Zn0.5Cd0.5S (abbreviated as YSN, yolk–shell nanoparticle) under NIR radiation will generate reactive oxygen species for imposing cytotoxicity. HDX, the only available autophagy inhibitor in clinical studies, can enhance cytotoxicity by preventing damaged organelles from being recycled. The cRGD-decorated cell membrane allowed the HDX-loaded nanoparticles to efficiently bypass the BBB and specifically target glioblastoma cells. Exceptional treatment efficacy of the NIR-triggered chemotherapy and photodynamic therapy was achieved in U87 cells and in the mouse glioblastoma model as well. Our results provided proof-of-concept evidence that HDX@YSN@CCM@cRGD could overcome the delivery barriers and achieve targeted treatment of glioblastoma.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangxi Clinical Research Center for Neurological Diseases, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China

School of Chemistry and Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales 2052, Australia

Laboratory of Neurology, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China

School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia

School of Pharmacy, Guilin Medical University, Guilin 541001, China

Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China

School of Allied Health, University of Western Australia, Perth, Western Australia 6009, Australia

Department of Neurology, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China

Key Laboratory of Brain and Cognition of Guangxi Province, Guilin Medical University, Guilin 541001, China

Guangxi Engineering Research Center for Digital Medicine and Clinical Translation, Guilin Medical University, Guilin 541001, China

Guangxi Key Laboratory of Big Data Intelligent Cloud Management for Neurological Diseases, Guilin Medical University, Guilin 541001, China

Funding

Natural Science Foundation of Guangxi Province · Guilin Scientific Research and Technology Development Plan · Guangxi Zhuang Region Health Department · Science and Technology Department of Guangxi Zhuang Autonomous · Guangxi Zhuang Autonomous Region

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