In SituBiosynthesis of a Metal Nanoparticle Encapsulated in Alginate Gel for Imageable Drug-Delivery System

Moon Il Kim; Chan Yeong Park; Ji Min Seo; Kyoung Suk Kang; Ki Soo Park; Jongeun Kang; Kwan Soo Hong; Yoojin Choi; Sang Yup Lee; Jong Pil Park; Hyun Gyu Park; Tae Jung Park

doi:10.1021/acsami.1c02286

journal article·2021-08-11

In SituBiosynthesis of a Metal Nanoparticle Encapsulated in Alginate Gel for Imageable Drug-Delivery System

Moon Il Kim, Chan Yeong Park, Ji Min Seo, Kyoung Suk Kang, Ki Soo Park, Jongeun Kang, Kwan Soo Hong, Yoojin Choi, Sang Yup Lee, Jong Pil Park, Hyun Gyu Park, Tae Jung Park

ACS Applied Materials & Interfaces· Volume 13· Issue 31

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Source abstract

Abstract

Development of drug-delivery systems that allow simultaneous in vivo imaging has gained much interest. We report a novel strategy to encapsulate metal nanoparticles (NPs) within alginate gel for in vivo imaging. The cell lysate of recombinant Escherichia coli strain, expressing Arabidopsis thaliana phytochelatin synthase and Pseudomonas putida metallothionein genes, was encapsulated within the alginate gel. Incubation of alginate gel with metal ion precursors followed by UV irradiation resulted in the synthesis of high concentrations of metal NPs, such as Au, Ag, CdSe, and EuSe NPs, within the gel. The alginate gel with metal NPs was used as a drug-delivery system by further co-encapsulating doxorubicin and rifampicin, the release of which was made to be pH-dependent. This system can be conveniently and safely used for in vitro and in vivo bioimaging, enabled by the metal NPs formed within the gel matrix without using toxic reducing reagents or surfactants.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering (BK21+ Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam, Gyeonggi-do 13120, Republic of Korea

Department of Chemistry, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea

Department of Biological Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea

Bioimaging Research Team, Korea Basic Science Institute, 162 Yeongudanji-ro, Ochang-eup, Cheongju, Chungcheongbuk-do 28119, Republic of Korea

Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea

Department of Food Science and Biotechnology, School of Food Science and Technology, Chung-Ang University, 4726 Seodong-daero, Anseong 17546, Republic of Korea

Funding

National Research Foundation of Korea

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