journal article·2021

Ferrous ions doped layered double hydroxide: smart 2D nanotheranostic platform with imaging-guided synergistic chemo/photothermal therapy for breast cancer

Zhenhu Guo, Wensheng Xie, Jingsong Lu, Xiaoxiao Guo, Yongjie Chi, Dan Wang, Nonaka Takuya, Wanling Xu, Jielin Ye, Xiangyan Liu, Zi Gu, Benhua Xu, Hong Wu, Lingyun Zhao

Biomaterials Science· Volume 9· Issue 17
Publisher page

Abstract

-weighted MRI effect revealed that the as-prepared Fe-LDH/DOX is sensitive to the tumor acid microenvironment. Most importantly, the growth rate of tumors in 4T1 bearing mice could be effectively inhibited after the synergistic treatment of PTT and chemotherapy by Fe-LDH/DOX. These results show that doping functional metal ions into LDH NPs may open a novel approach to fabricating an LDH NP-based nanotheranostics platform with advanced diagnostic and therapeutic performances.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques · Ga2O3 and related materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Powder Metallurgy, Powder Metallurgy Research Institute, Central South University, Changsha 410083, China

Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China

Department of Nanoengineering, Chemical Engineering Program, and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA

Department of General Surgery, Xiangya Hospital, Central South University, Clinical Research Center For Breast Cancer Control and Prevention In Hunan Province, Changsha, 410008, China

School of Chemical Engineering and Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW 2052, Australia

Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, 350001, China

Funding

National Natural Science Foundation of China · Hunan Provincial Innovation Foundation for Postgraduate

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