Engineering the Coacervate Microdroplet Interface via Polyelectrolyte and Surfactant Complexation

Chengying Yin; Zi Lin; Xingyu Jiang; Nicolas Martin; Liangfei Tian

doi:10.1021/acsami.3c00727

journal article·2023-06-14Open access

Engineering the Coacervate Microdroplet Interface via Polyelectrolyte and Surfactant Complexation

Chengying Yin, Zi Lin, Xingyu Jiang, Nicolas Martin, Liangfei Tian

ACS Applied Materials & Interfaces· Volume 15· Issue 23

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Source abstract

Abstract

Complex coacervate microdroplets, which are formed via spontaneous liquid-liquid phase separation by mixing two oppositely charged polyelectrolytes in water, have emerged as a new paradigm in the fields of origin of life, membraneless subcellular compartmentalization, bioreactors, and drug delivery. However, how to further improve its stability and enhance its selectivity in one particular coacervate system remains a challenge. By generating a membrane-like layer at the surface of coacervate microdroplets via electrostatic interactions between oppositely charged surfactants and polyelectrolytes, we here achieve tunable permeability and enhanced stability of the coacervates at the same time. Depending on the surfactants used, membrane-like layer-coated coacervate microdroplets exhibit different selectivity over solute sequestration and can promote or inhibit DNA hybridization. Our approach provides a practical tool to engineer functional bioinspired microcompartments with potential applications in the fields of controlled drug release and microreactor technology.

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Research context

OpenAlex topics: Pickering emulsions and particle stabilization · Polymer Surface Interaction Studies · Proteins in Food Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

Université de Bordeaux, CNRS, Centre de Recherche Paul Pascal, UMR 5031, 115 Avenue Du Dr. Schweitzer, Pessac 33600, France

Department of Ultrasound, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310027, China

Innovation Center for Smart Medical Technologies & Devices, Binjiang Institute of Zhejiang University, Hangzhou 310053, China

Funding

International Centre for Genetic Engineering and Biotechnology · Zhejiang University · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Zhijiang Laboratory, Zhejiang University

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