Graphene Hydrogel as a Porous Scaffold for Cartilage Regeneration

Chengqi Lyu; Chi Cheng; YuShi He; Ling Qiu; Zijun He; Derong Zou; Dan Li; Jiayu Lu

doi:10.1021/acsami.2c11307

journal article·2022-12-14

Graphene Hydrogel as a Porous Scaffold for Cartilage Regeneration

Chengqi Lyu, Chi Cheng, YuShi He, Ling Qiu, Zijun He, Derong Zou, Dan Li, Jiayu Lu

ACS Applied Materials & Interfaces· Volume 14· Issue 49

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Source abstract

Abstract

Porous scaffolds have widely been exploited in cartilage tissue regeneration. However, it is often difficult to understand how the delicate hierarchical structure of the scaffold material affects the regeneration process. Graphene materials are versatile building blocks for robust and biocompatible porous structures, enabling investigation of structural cues on tissue regeneration otherwise challenging to ascertain. Here, we utilize a graphene hydrogel with stable and tunable structure as a model scaffold to examine the effect of porous structure on matrix remodeling associated with ingrowth of chondrocytes on scaffolds. We observe much-accelerated yet balanced cartilage remodeling correlating the ingrowth of chondrocytes into the graphene scaffold with an open pore structure on the surface. Importantly, such an enhanced remodeling selectively promotes the expression of collagen type II fibrils over proteoglycan aggrecan, hence clearly illustrating that chondrocytes maintain a stable phenotype when they migrate into the scaffold while offering new insights into scaffold design for cartilage repair.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials Biomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Bone Tissue Engineering Materials · Osteoarthritis Treatment and Mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Stomatology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, P. R. China

Department of Chemical Engineering, The University of Melbourne, Parkville, VIC 3010, Australia

Shanghai Electrochemical Energy Devices Research Center, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

Shenzhen Geim Graphene Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, P. R. China

Funding

National Natural Science Foundation of China · Youth top-notch talent development plan of Shanghai · Advanced Research Program of Shanghai Jiao Tong University Affiliated Sixth People's Hospital · Double hundred Project of Medical School of Shanghai Jiao Tong University · Innovative research team of high-level local universities in Shanghai

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