DataVXACS Applied Materials & InterfacesPaper
journal article·2020-11-18Open access

Autofluorescence-Free In Vivo Imaging Using Polymer-Stabilized Nd3+-Doped YAG Nanocrystals

Alexandra Cantarano, Jingke Yao, Marija Matulionyte, José Lifante, Antonio Benayas, Dirk H. Ortgies, Fiorenzo Vetrone, Alain Ibanez, Corine Gérardin, Daniel Jaque, Géraldine Dantelle

ACS Applied Materials & Interfaces· Volume 12· Issue 46
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Source abstract

Abstract

Neodymium-doped yttrium aluminum garnet (YAG:Nd3+) has been widely developed during roughly the past 60 years and has been an outstanding fluorescent material. It has been considered as the gold standard among multipurpose solid-state lasers. Yet, the successful downsizing of this system into the nanoregimen has been elusive, so far. Indeed, the synthesis of a garnet structure at the nanoscale, with enough crystalline quality for optical applications, was found to be quite challenging. Here, we present an improved solvothermal synthesis method producing YAG:Nd3+ nanocrystals of remarkably good structural quality. Adequate surface functionalization using asymmetric double-hydrophilic block copolymers, constituted of a metal-binding block and a neutral water-soluble block, provides stabilized YAG:Nd3+ nanocrystals with long-term colloidal stability in aqueous suspensions. These newly stabilized nanoprobes offer spectroscopic quality (long lifetimes, narrow emission lines, and large Stokes shifts) close to that of bulk YAG:Nd3+. The narrow emission lines of YAG:Nd3+ nanocrystals are exploited by differential infrared fluorescence imaging, thus achieving an autofluorescence-free in vivo readout. In addition, nanothermometry measurements, based on the ratiometric fluorescence of the stabilized YAG:Nd3+ nanocrystals, are demonstrated. The progress here reported paves the way for the implementation of this new stabilized YAG:Nd3+ system in the preclinical arena.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Luminescence Properties of Advanced Materials · Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Université Grenoble Alpes, CNRS, Grenoble INP, Institut Néel, 38000 Grenoble, France

Fluorescence Imaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente 7, 28049 Madrid, Spain

Institut National de la Recherche Scientifique, Centre Énergie, Matériaux et Télécommunications, Université du Québec, 1650 Boul. Lionel-Boulet, Varennes (Québec) J3X 1S2, Canada

Fluorescence Imaging Group, Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Avda. Arzobispo Morcillo, 2, Madrid 28029, Spain

Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Ctra. Colmenar km 9.100, 28034 Madrid, Spain

ICGM, Univ. Montpellier, CNRS UMR 5253, ENSCM, 240 Avenue E. Jeanbrau, 34296 Montpellier cedex 5, France

Funding

Agence Nationale de la Recherche · Comunidad de Madrid · Ministerio de Ciencia, Innovaci?n y Universidades · European Commission · Ministerio de Econom?a y Competitividad · Fonds de Recherche du Qu?bec - Nature et Technologies · H2020 Future and Emerging Technologies · European Cooperation in Science and Technology · Centre National de la Recherche Scientifique · China Scholarship Council · Instituto de Salud Carlos III · Natural Sciences and Engineering Research Council of Canada

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