DataVXACS Applied Materials & InterfacesPaper
journal article·2017-08-23

Tailoring the Oxygen Reduction Activity of Hemoglobin through Immobilization within Microporous Organic Polymer–Graphene Composite

Ahmed B. Soliman, Rana R. Haikal, Arwa A. Abugable, Mohamed H. Hassan, Stavros G. Karakalos, Perry J. Pellechia, Hamdy H. Hassan, Magdi H. Yacoub, Mohamed H. Alkordi

ACS Applied Materials & Interfaces· Volume 9· Issue 33
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Source abstract

Abstract

A facile one-pot, bottom-up approach to construct composite materials of graphene and a pyrimidine-based porous-organic polymer (PyPOP), as host for immobilizing human hemoglobin (Hb) biofunctional molecules, is reported. The graphene was selected because of its excellent electrical conductivity, while the PyPOP was utilized because of its pronounced permanent microporosity and chemical functionality. This approach enabled enclathration of the hemoglobin within the microporous composite through a ship-in-a-bottle process, where the composite of the PyPOP@G was constructed from its molecular precursors, under mild reaction conditions. The composite-enclathrated Fe-protoporphyrin-IX demonstrated electrocatalytic activity toward oxygen reduction, as a functional metallocomplex, yet with a distinct microenvironment provided by the globin protein. This approach delineates a pathway for platform microporous functional solids, where fine-tuning of functionality is facilitated by judicious choice of the active host molecules or complexes, targeting specific application.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsCompositesCatalysis & surfaces

OpenAlex topics: Covalent Organic Framework Applications · Metal-Organic Frameworks: Synthesis and Applications · Fuel Cells and Related Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Materials Science, Zewail City of Science and Technology, Sheikh Zayed Dist., 12588, Giza, Egypt

Chemistry Department, Faculty of Science, Ain-Shams University, Abbasia, Cairo, 11566, Egypt

Center of Genomics, Helmy Institute, Zewail City of Science and Technology, Sheikh Zayed Dist., 12588, Giza, Egypt

College of Engineering and Computing, Swearingen Engineering Center, University of South Carolina, Columbia, South Carolina 29208, United States

Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States

Heart Science Centre, Imperial College, Harefield, Uxbridge UB9 6JH, United Kingdom

Funding

Science and Technology Development Fund · Harefield Heart Science Centre, Magdi Yacoub Institute · Heart Biotech Nano Limited · Center for Materials Science, Zewail City of Science and Technology

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