Amphiphilic Nano-Swords for Direct Penetration and Eradication of Pathogenic Bacterial Biofilms

Cailing Zhou; Yu Zhou; Yaqian Zheng; Yue Yu; Kailing Yang; Zhiyong Chen; Xianhui Chen; Kang Wen; Yajie Chen; Silei Bai; Junfeng Song; Tong Wu; E. Lei; Muyang Wan; Qingyun Cai; Luyan Ma; Wing-Leung Wong; Yugang Bai; Chunhui Zhang; Xinxin Feng

doi:10.1021/acsami.3c03091

journal article·2023-04-26Open access

Amphiphilic Nano-Swords for Direct Penetration and Eradication of Pathogenic Bacterial Biofilms

Cailing Zhou, Yu Zhou, Yaqian Zheng, Yue Yu, Kailing Yang, Zhiyong Chen, Xianhui Chen, Kang Wen, Yajie Chen, Silei Bai, Junfeng Song, Tong Wu, E. Lei, Muyang Wan, Qingyun Cai, Luyan Ma, Wing-Leung Wong, Yugang Bai, Chunhui Zhang, Xinxin Feng

ACS Applied Materials & Interfaces· Volume 15· Issue 16

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Source abstract

Abstract

Bacterial biofilms are major causes of persistent and recurrent infections and implant failures. Biofilms are formable by most clinically important pathogens worldwide, such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, causing recalcitrance to standard antibiotic therapy or anti-biofilm strategies due to amphiphilic impermeable extracellular polymeric substances (EPS) and the presence of resistant and persistent bacteria within the biofilm matrix. Herein, we report our design of an oligoamidine-based amphiphilic “nano-sword” with high structural compacity and rigidity. Its rigid, amphiphilic structure ensures effective penetration into EPS, and the membrane-DNA dual-targeting mechanism exerts strong bactericidal effect on the dormant bacterial persisters within biofilms. The potency of this oligoamidine is shown in two distinct modes of application: it may be used as a coating agent for polycaprolactone to fully inhibit surface biofilm growth in an implant-site mimicking micro-environment; meanwhile, it cures model mice of biofilm infections in various ex vivo and in vivo studies.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Biomaterials

OpenAlex topics: Antimicrobial agents and applications · Bacterial biofilms and quorum sensing · Antimicrobial Peptides and Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and School of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

University of Chinese Academy of Sciences, Beijing 100049, China

College of Biology, Hunan University, Changsha, Hunan 410082, China

State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR 999077, China

Funding

Research Grants Council, University Grants Committee · Natural Science Foundation of?Hunan Province · Central University Basic Research Fund of China · National Natural Science Foundation of China

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