DataVXACS Applied Materials & InterfacesPaper
journal article·2021-01-20

Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Valeriya Kudryavtseva, Stefania Boi, Jordan Read, Raphael Guillemet, Jiaxin Zhang, Andrei Udalov, Evgeny Shesterikov, Sergei Tverdokhlebov, Laura Pastorino, David J. Gould, Gleb B. Sukhorukov

ACS Applied Materials & Interfaces· Volume 13· Issue 2
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Source abstract

Abstract

This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core-shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small water-soluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 μm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Polymer Surface Interaction Studies · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Nanoforce Technology Ltd, School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom

National Research Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russian Federation

Department of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genoa, Via all’Opera Pia 13, 16145 Genoa, Italy

Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom

THALES Research & Technology, 1 Avenue Augustin Fresnel, 91767 Palaiseau, France

V.E. Zuev Institute of Atmospheric Optics SB RAS, 1 Academician Zuev Square, Tomsk 634055, Russian Federation

Tomsk State University of Control Systems and Radioelectronics, 40 Lenin Avenue, Tomsk 634050, Russian Federation

Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Bld. 1, Moscow 143025, Russian Federation

Funding

Tomsk Polytechnic University · Versus Arthritis · H2020 Industrial Leadership

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