Particulate-Aggregated Adhesives with Exudate-Sensitive Properties and Sustained Bacteria Disinfection to Facilitate Wound Healing
Source abstract
Abstract
Wound-associated infections create additional suffering and come at a high cost for patients and their families, which urgently require wound disinfection biomaterials with improved healing efficacy. Here, we report an adhesive with sustained bacteria disinfection ability, which is aggregated from hydrogen-bonded polymer particulates. The particulate-aggregated adhesive shows strong binding ability on different surfaces from rigid substrates to soft skins. Moreover, water-sensitive mechanical properties are shown in wound exudates, resulting from the dissociation of hydrogen bonds under the competition of water and thus the sustained release of particulates. Synergizing with the strong binding ability, exudate-sensitive behaviors, and sustained release of antibacterial particulates, the adhesive achieves sustained bactericidal activity and can facilitate the healing process in bacteria-infected skin wounds.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Antimicrobial agents and applications · Wound Healing and Treatments · Surgical Sutures and Adhesives
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, P. R. China
Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Street, Yuexiu District, Guangzhou 510080, P. R. China
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, Tianjin 300457, P. R. China
City University of Hong Kong, Shenzhen Research Institute, Shenzhen 518075, P. R. China
Funding
Research Grants Council, University Grants Committee · City University of Hong Kong · Shenzhen Municipality
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