DataVXACS Applied Materials & InterfacesPaper
journal article·2020-05-20Open access

Dual-Color Plasmonic Nanosensor for Radiation Dosimetry

Yu Tao, Mingqiang Li, Xiangyu Liu, Kam W. Leong, Jean Gautier, Shan Zha

ACS Applied Materials & Interfaces· Volume 12· Issue 20
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Source abstract

Abstract

Radiation dosimeters are critical for accurately assessing the levels of radiation exposure of tumor sites and surrounding tissues and for optimizing therapeutic interventions as well as for monitoring environmental exposure. To fill the need for a simple, user-friendly, and inexpensive dosimeter, we designed an innovative colorimetric nanosensor-based assay for detecting ionizing radiation. We show that hydroxyl radicals generated by ionizing radiation can be used to etch gold nanorods (AuNRs) and silver nanoprisms (AgNPRs), yielding reproducible color changes for radiation dose detection in the range of 50-2000 rad, broad enough to cover doses used in hyperfractionated, conventional, and hypofractionated radiotherapy. This range of doses detected by this assay correlates with radiation-induced DNA damage response in mammalian cells. Furthermore, this AuNR- and AgNPR-based sensing platform has been established in a paper format that can be readily adopted for a wide range of applications and translation.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Molecular Communication and Nanonetworks · Gold and Silver Nanoparticles Synthesis and Applications · Radiation Therapy and Dosimetry

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute for Cancer Genetics, Columbia University, New York, New York 10032, United States

Laboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

Department of Biomedical Engineering, Columbia University, New York, New York 10027, United States

Department of Genetics and Development, Columbia University, New York, New York 10032, United States

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, United States

Department of Pediatrics, Pathology and Cell Biology, Immunology and Microbiology, Columbia University, New York, New York 10032, United States

Funding

National Natural Science Foundation of China · National Institutes of Health · Guangdong Province Science and Technology Innovation Special Fund

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