Poly(styrenesulfonate)-Modified Ni–Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform
Source abstract
Abstract
Drug-eluting stents (DESs) are widely used in the palliative treatment of many kinds of cancers. However, the covered polymers used in DESs are usually associated with stent migration and acute cholecystitis. Therefore, developing noncovered drug-loading layers on metal stents is of great importance. In this work, Ni-Ti layered double hydroxide (Ni-Ti LDH) films were prepared on the surface of nitinol via hydrothermal treatment, and the LDH films were further modified by poly(styrenesulfonate) (PSS). The anticancer drug doxorubicin could be effectively loaded onto the modified films, and drug release could be smartly controlled by the pH. Besides, the drug absorption amounts of cancer cells cultured on the films could be effectively improved. These results indicate that the PSS-modified LDH film may become a promising drug-loading platform that can be used in the design of DESs.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Layered Double Hydroxides Synthesis and Applications · Magnesium Oxide Properties and Applications · Supercapacitor Materials and Fabrication
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Intervention Center, Eastern Hepatobilialy Surgery Hospital, The Second Military Medical University, Shanghai 200438, China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Funding
National Natural Science Foundation of China · Municipal Hospital Joint Research Project of Emerging Frontier Technology · Shanghai Committee of Science and Technology · Shen Kang Group
References (52)
Show source-provided references
1. 10.1148/radiology.215.3.r00jn3065910.1148/radiology.215.3.r00jn30659 ↗
2. 10.1016/S0921-5093(99)00294-410.1016/S0921-5093(99)00294-4 ↗
3. 10.1016/S1499-3872(11)60001-510.1016/S1499-3872(11)60001-5 ↗
4. 10.1038/nature1323210.1038/nature13232 ↗
5. 10.1016/j.biomaterials.2015.03.00910.1016/j.biomaterials.2015.03.009 ↗
6. 10.1016/j.biomaterials.2014.12.01510.1016/j.biomaterials.2014.12.015 ↗
7. 10.1016/j.actbio.2016.03.01010.1016/j.actbio.2016.03.010 ↗
8. 10.1016/j.biomaterials.2013.03.06710.1016/j.biomaterials.2013.03.067 ↗
9. 10.1016/j.msec.2013.10.03310.1016/j.msec.2013.10.033 ↗
10. 10.1016/j.surfcoat.2015.06.00710.1016/j.surfcoat.2015.06.007 ↗
11. 10.2217/nnm.13.9310.2217/nnm.13.93 ↗
12. 10.1007/s13233-014-2095-910.1007/s13233-014-2095-9 ↗
13. 10.2147/IJN.S5125810.2147/IJN.S51258 ↗
14. 10.1016/j.colsurfb.2009.05.01610.1016/j.colsurfb.2009.05.016 ↗
15. 10.1016/j.jconrel.2006.08.02310.1016/j.jconrel.2006.08.023 ↗
16. 10.1016/j.biomaterials.2010.02.00310.1016/j.biomaterials.2010.02.003 ↗
17. 10.1016/j.colsurfb.2010.01.01910.1016/j.colsurfb.2010.01.019 ↗
18. 10.1016/j.matlet.2012.08.08410.1016/j.matlet.2012.08.084 ↗
19. 10.1016/j.jconrel.2012.07.00410.1016/j.jconrel.2012.07.004 ↗
20. 10.1016/j.biomaterials.2015.11.03710.1016/j.biomaterials.2015.11.037 ↗
21. 10.1016/j.bios.2015.06.02310.1016/j.bios.2015.06.023 ↗
22. 10.1016/j.biomaterials.2015.11.04910.1016/j.biomaterials.2015.11.049 ↗
23. 10.1021/acs.chemrev.5b0045610.1021/acs.chemrev.5b00456 ↗
24. 10.1002/adma.20150421910.1002/adma.201504219 ↗
25. 10.1016/j.biomaterials.2015.12.01810.1016/j.biomaterials.2015.12.018 ↗
26. 10.1002/adma.20140257210.1002/adma.201402572 ↗
27. 10.1039/c3tb00518f10.1039/c3tb00518f ↗
28. 10.1021/cr200434v10.1021/cr200434v ↗
29. 10.1002/adfm.20110222210.1002/adfm.201102222 ↗
30. 10.1016/j.actbio.2015.10.02910.1016/j.actbio.2015.10.029 ↗
31. 10.1021/acsami.5b0456910.1021/acsami.5b04569 ↗
32. 10.1371/journal.pone.013653010.1371/journal.pone.0136530 ↗
33. 10.1021/ja105809e10.1021/ja105809e ↗
34. 10.1007/s10856-013-4932-310.1007/s10856-013-4932-3 ↗
35. 10.1016/j.msec.2014.03.01310.1016/j.msec.2014.03.013 ↗
36. 10.1021/acsami.5b0108710.1021/acsami.5b01087 ↗
37. 10.1039/C5RA18740K10.1039/C5RA18740K ↗
38. 10.1002/adma.20150373010.1002/adma.201503730 ↗
39. 10.1016/j.biomaterials.2013.09.06010.1016/j.biomaterials.2013.09.060 ↗
40. 10.1021/jacs.5b0076210.1021/jacs.5b00762 ↗
41. 10.1016/j.mvr.2007.05.00310.1016/j.mvr.2007.05.003 ↗
42. 10.1016/j.dld.2006.07.01310.1016/j.dld.2006.07.013 ↗
43. 10.1038/nrc171310.1038/nrc1713 ↗
44. 10.1016/j.bbcan.2005.06.00410.1016/j.bbcan.2005.06.004 ↗
45. 10.1002/adma.20120508810.1002/adma.201205088 ↗
46. 10.1073/pnas.080176310510.1073/pnas.0801763105 ↗
47. 10.1016/j.neuroscience.2010.10.00210.1016/j.neuroscience.2010.10.002 ↗
48. 10.1371/journal.pone.008497510.1371/journal.pone.0084975 ↗
49. 10.1016/j.chemphyslip.2009.07.00410.1016/j.chemphyslip.2009.07.004 ↗
50. 10.1016/j.biomaterials.2014.08.00810.1016/j.biomaterials.2014.08.008 ↗
51. 10.1016/S0006-2952(99)00022-210.1016/S0006-2952(99)00022-2 ↗
52. 10.1016/S0006-2952(03)00467-210.1016/S0006-2952(03)00467-2 ↗