Amphipathic Nanodiamond Supraparticles for Anticancer Drug Loading and Delivery

Nanodiamonds (NDs) have been attracting considerable attention due to their outstanding chemical, physical, and physiological properties. Additional functionalization of NDs can be carried out by the self-assembly technique. This study reports a straightforward chemical route for self-assembled supraparticles (SPs) based on ND (ND-SPs) using alkyl carboxylic acids with different aliphatic alkyl chain lengths by carbodiimide chemistry and sonication. Poly(ethylene glycol) (PEG)-modified ND-SPs are synthesized successfully for effective nanodrug formulations with the hydrophobic anticancer drug paclitaxel (PTX). The properties of these ND-SP nanomedicines are investigated thoroughly by complementary analytical, spectroscopic, and microscopic techniques. This simple methodology permitted the application of PEG-modified ND-SP-encapsulating PTX as a potent drug carrier, achieving greater efficacy than commercial Abraxane. Results revealed that the morphology, particle size, and water dispersibility of the prepared ND-SP nanoclusters affect the drug efficacy. These PEG-modified ND-SP nanoclusters serve as novel nanomedicine for a passive drug delivery system as well as anticancer chemotherapy.