journal article·2018-10-31

Prolonged Drug-Releasing Fibers Attenuate Alzheimer’s Disease-like Pathogenesis

Geisa Nogueira Salles, Michele Longoni Calió, Samson Afewerki, Cristina Pacheco-Soares, Marimelia Porcionatto, Christian Hölscher, Anderson O. Lobo

ACS Applied Materials & Interfaces· Volume 10· Issue 43
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Abstract

Delivering drugs and agents to the brain is a huge challenge, especially for chronic neurodegenerative disorders, such as Alzheimer's disease (AD). For this, prolonged and sustained release methods to increase brain uptake represent an impacting concept. The bioresorbable polymer poly-lactic acid (PLA) has high potential for medical implants; at the same time, glucagon-like peptide-1 (GLP-1) analogues have considerable neuroprotective attributes and represent a therapeutic strategy for AD. Here, a biodevice is produced by electrospinning PLA with a GLP-1 analogue (liraglutide, LG), coated with a thin layer of gelatin. The biodevice is subcutaneously implanted in a transgenic mouse model of AD and LG is released for 14 days in mice serum. After 4 weeks of implantation, crucial hallmarks of the AD are highly diminished: hippocampal senile amyloid β plaque load and neuroinflammatory markers. Furthermore, neurogenesis is enhanced in the subventricular zone, an important neurogenic niche in the brain. The designed biodevice holds great promise for being an affordable candidate to act as a prolonged drug provider, promoting LG mission through increasing its lifetime, constituting a relevant approach for old and impaired brain.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Alzheimer's disease research and treatments · Nerve injury and regeneration

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Dynamics of Cellular Compartments, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao Jose dos Campos 12244-000, São Paulo, Brazil

Department of Biochemistry, Neurobiology Laboratory, Escola Paulista de Medicina, Universidade Federal São Paulo, São Paulo 04021-00, Brazil

Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, U.K.

Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women’s Hospital, Cambridge, Massachusetts 02139, United States

Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Institute of Science and Technology, Universidade Brasil, Itaquera 08230-030, São Paulo, Brazil

LIMAv—Interdisciplinary Laboratory for Advanced Materials, PPGCM—Materials Science and Engineering Graduate Program, UFPI—Federal University of Piaui, Teresina 64049-550, Piauí, Brazil

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, United States

Funding

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico · Sweden-America Foundation · Stiftelsen Olle Engkvist Byggm?stare · Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo · Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior · Stiftelsen Bengt Lundqvists Minne

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