journal article·2017-02-08

Spongelike Porous Silica Nanosheets: From “Soft” Molecular Trapping to DNA Delivery

Qingmin Ji, Tomohiko Yamazaki, Jiao Sun, Żaneta Górecka, Nien-Chi Huang, Shan-hui Hsu, Lok Kumar Shrestha, Jonathan P. Hill, Katsuhiko Ariga

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Abstract

Spongelike porous silica nanosheets, with nanometer thicknesses and pores whose diameters are on the hundreds-of-nanometers scale, have been used as a novel carrier for molecular immobilization of different guests. Enhanced properties of encapsulation were shown for drug molecules of different dimensions due to "softness" caused by the specific nanometric features of the porous structure. The encapsulating effect of the structure results in sustained and stimuli-responsive release behavior of immobilized guest molecules. By studying the adsorption process of DNA molecules on spongelike porous nanosheets or on solid nanoparticles by use of a quartz crystal microbalance, we show that better elasticity of surfaces of the porous nanosheets over that of solid nanoparticles can improve the immobilization of guest molecules. The coating of porous silica nanosheets onto various substrates was also found to effectively mediate DNA delivery to mammalian cells.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Mesoporous Materials and Catalysis · Polymer Surface Interaction Studies · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Herbert Gleiter Institute of Nanoscience, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing 210094, China

WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan

Faculty of Materials Science and Engineering, Warsaw University of Technology, Wołoska 141, Warsaw 02-507, Poland

Institute of Polymer Science and Engineering, National Taiwan University. No. 1 Sec. 4 Roosevelt Road, Taipei 10617, Taiwan

Funding

Ministry of Education of the People's Republic of China · Natural Science Foundation of Jiangsu Province · Japan Science and Technology Agency · Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology

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