Pt/DOX Nanomotors Enhance Penetration in the Deep Tumor by Positive Chemotaxis
Source abstract
Abstract
Inefficient tumor penetration caused by the characteristics of tumor microenvironments is a primary obstacle to improving drug delivery efficiency, which restricts the chemotherapy drug efficacy. One such promising idea is to construct micro/nanomotors (MNMs) as an effective delivery vehicle by way of producing autonomous motion and converting exogenous stimuli or external energies from the surrounding environment into mechanical forces. In this research, the Pt/DOX nanomotor was prepared, and the enhanced diffusion and positive chemotaxis driven by substrates were verified in vitro, proof of the enhanced cellular uptake and deep penetration of Pt/DOX. As a novel nanovehicle, Pt/DOX potentially provides an intriguing approach to foster the tumor-deep penetration and enhance the drug delivery efficiency.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Micro and Nano Robotics · Molecular Communication and Nanonetworks · Microtubule and mitosis dynamics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Pharmaceutics, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.R. China
Department of Anesthesiology, Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
Key Laboratory of Cancer Prevention and Intervention, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, P.R. China
Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Intervention, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, PR China
Westlake Laboratory of Life Science and Biomedicine, Hangzhou 310058, P.R. China
Cancer Center of Zhejiang University, Zhejiang University, Hangzhou 310058, P.R. China
State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, P.R. China
Funding
Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China
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