journal article·2022-07-13

Construction of a Hierarchical Micro-/Submicro-/Nanostructured 3D-Printed Ti6Al4V Surface Feature to Promote Osteogenesis: Involvement of Sema7A through the ITGB1/FAK/ERK Signaling Pathway

Jinkai Zhang, Cancan Zhao, Ruilong Sheng, Kaili Lin, Xudong Wang, Shilei Zhang

ACS Applied Materials & Interfaces· Volume 14· Issue 27
Publisher page

Abstract

Constructing hierarchical hybrid structures is considered a facile method to improve the osseointegration of implants. Herein, a hierarchical micro-/submicro-/nanostructured surface feature of Ti6Al4V implants (3DAT group) was successfully constructed by combining the inherently formed three-dimensional (3D)-printed microscale topography, acid-etched sub-micropits, and anodized nanotubes. Compared with the classical SLA surface, the microscale topography and sub-micropits increased the three-dimensional space for the cell growth and mechanical stability of implants, while the modification of nanotubes dramatically improved the surface hydrophilicity, protein adsorption, and biomineralization. Most importantly, the 3DAT surface feature possessed excellent osteogenic performance in vitro and in vivo, with the involvement of semaphorin 7A (Sema7A) as revealed by RNA-seq through the ITGB1/FAK/ERK signaling pathway. The present study suggested that the hierarchically structured surface design strategy could accelerate the osseointegration rate of 3D-printed Ti6Al4V implants, promising personalized reconstruction of bone defects.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Axon Guidance and Neuronal Signaling · Titanium Alloys Microstructure and Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China

Department of Orthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China

CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, Funchal 9000-390, Madeira, Portugal

Funding

Shanghai Jiao Tong University · Agência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Fundação para a Ciência e a Tecnologia · CAMS Innovation Fund for Medical Sciences · Double Hundred Plan

References (48)

Show source-provided references
1. 10.1016/j.biomaterials.2016.01.01210.1016/j.biomaterials.2016.01.012 ↗
2. 10.1016/j.matlet.2016.10.06410.1016/j.matlet.2016.10.064 ↗
3. 10.1016/j.actbio.2018.08.01310.1016/j.actbio.2018.08.013 ↗
4. 10.1021/acsami.1c1120710.1021/acsami.1c11207 ↗
5. 10.1177/2041731421105723610.1177/20417314211057236 ↗
6. 10.1177/204173142096579710.1177/2041731420965797 ↗
7. 10.1016/j.jmst.2018.09.06310.1016/j.jmst.2018.09.063 ↗
8. 10.1016/j.bioactmat.2019.12.00810.1016/j.bioactmat.2019.12.008 ↗
9. 10.1016/j.jmst.2019.12.03010.1016/j.jmst.2019.12.030 ↗
10. 10.1016/j.biomaterials.2010.03.01410.1016/j.biomaterials.2010.03.014 ↗
11. 10.3389/fbioe.2021.59179610.3389/fbioe.2021.591796 ↗
12. 10.1021/acsami.1c0214010.1021/acsami.1c02140 ↗
13. 10.2147/IJN.S12676010.2147/IJN.S126760 ↗
14. 10.1016/j.msec.2018.08.06910.1016/j.msec.2018.08.069 ↗
15. 10.1038/s41413-021-00180-y10.1038/s41413-021-00180-y ↗
16. 10.1016/j.msec.2017.02.15010.1016/j.msec.2017.02.150 ↗
17. 10.1016/j.biomaterials.2011.12.02410.1016/j.biomaterials.2011.12.024 ↗
18. 10.1038/nrg248410.1038/nrg2484 ↗
19. 10.1042/BC2004010310.1042/BC20040103 ↗
20. 10.1007/s10038-005-0331-z10.1007/s10038-005-0331-z ↗
21. 10.1002/jbm.a.3532610.1002/jbm.a.35326 ↗
22. 10.3892/mmr.2017.617810.3892/mmr.2017.6178 ↗
23. 10.1089/scd.2020.001310.1089/scd.2020.0013 ↗
24. 10.1016/0142-9612(91)90194-F10.1016/0142-9612(91)90194-F ↗
25. 10.1016/j.biomaterials.2006.01.01710.1016/j.biomaterials.2006.01.017 ↗
26. 10.1021/acsami.9b1605010.1021/acsami.9b16050 ↗
27. 10.1021/acsami.6b1643010.1021/acsami.6b16430 ↗
28. 10.1089/ten.teb.2013.072810.1089/ten.teb.2013.0728 ↗
29. 10.1096/fasebj.4.13.221015710.1096/fasebj.4.13.2210157 ↗
30. 10.1034/j.1600-0501.2003.00972.x10.1034/j.1600-0501.2003.00972.x ↗
31. 10.1021/acsami.6b0589310.1021/acsami.6b05893 ↗
32. 10.1111/prd.1217910.1111/prd.12179 ↗
33. 10.1016/S0142-9612(99)00160-X10.1016/S0142-9612(99)00160-X ↗
34. 10.4248/BR20130300210.4248/BR201303002 ↗
35. 10.1021/acsbiomaterials.7b0031510.1021/acsbiomaterials.7b00315 ↗
36. 10.1016/j.actbio.2019.07.00710.1016/j.actbio.2019.07.007 ↗
37. 10.1038/ni155310.1038/ni1553 ↗
38. 10.1007/s12016-013-8360-410.1007/s12016-013-8360-4 ↗
39. 10.1038/nature1100010.1038/nature11000 ↗
40. 10.1016/j.bone.2020.11526010.1016/j.bone.2020.115260 ↗
41. 10.1186/s13075-016-1217-510.1186/s13075-016-1217-5 ↗
42. 10.1038/nature0565210.1038/nature05652 ↗
43. 10.1046/j.1365-3083.2002.01129.x10.1046/j.1365-3083.2002.01129.x ↗
44. 10.1038/nature0179010.1038/nature01790 ↗
45. 10.1126/science.279.5350.50910.1126/science.279.5350.509 ↗
46. 10.1016/j.semcdb.2013.01.00210.1016/j.semcdb.2013.01.002 ↗
47. 10.4049/jimmunol.174.1.5110.4049/jimmunol.174.1.51 ↗
48. 10.1038/jid.2008.32910.1038/jid.2008.329 ↗