journal article·2022-06-29

Scalable Milk-Derived Whey Protein Hydrogel as an Implantable Biomaterial

Ziyi Hu, Wangbei Cao, Liyin Shen, Ziyang Sun, Kang Yu, Qinchao Zhu, Tanchen Ren, Liwen Zhang, Houwei Zheng, Changyou Gao, Yong He, Chengchen Guo, Yang Zhu, Daxi Ren

ACS Applied Materials & Interfaces· Volume 14· Issue 25
Publisher page

Abstract

There are limited naturally derived protein biomaterials for the available medical implants. High cost, low yield, and batch-to-batch inconsistency, as well as intrinsically differing bioactivity in some of the proteins, make them less beneficial as common implant materials compared to their synthetic counterparts. Here, we present a milk-derived whey protein isolate (WPI) as a new kind of natural protein-based biomaterial for medical implants. The WPI was methacrylated at 100 g bench scale, >95% conversion, and 90% yield to generate a photo-cross-linkable material. WPI-MA was further processed into injectable hydrogels, monodispersed microspheres, and patterned scaffolds with photo-cross-linking-based advanced processing methods including microfluidics and 3D printing. In vivo evaluation of the WPI-MA hydrogels showed promising biocompatibility and degradability. Intramyocardial implantation of injectable WPI-MA hydrogels in a model of myocardial infarction attenuated the pathological changes in the left ventricle. Our results indicate a possible therapeutic value of WPI-based biomaterials and give rise to a potential collaboration between the dairy industry and the production of medical therapeutics.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310029, China

Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

School of Engineering, Westlake University, Hangzhou, Zhejiang 310023, China

State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China

Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China

Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310027, China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Guangxi Province · Shanghai Institute for Advanced Study, Zhejiang University

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