DataVXACS Applied Materials & InterfacesPaper
journal article·2021-07-28

Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques

Dan Mu, Wenshen Wang, Jianhui Li, Pin Lv, Renyuan Liu, Ying Tan, Chongxia Zhong, Yu Qi, Xuan Sun, Yihai Liu, Song Shen, Yuyu Li, Biao Xu, Bing Zhang

ACS Applied Materials & Interfaces· Volume 13· Issue 29
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Source abstract

Abstract

Macrophage accumulation is central to the pathogenesis of atherosclerotic plaques. Reducing macrophages in plaques is an appealing approach to attenuate the development of atherosclerosis. Chemodynamic therapy, specifically inhibiting hydrogen peroxide (H2O2)-rich cells in slightly acidic microenvironment, has emerged as a new method in tumor treatment. Herein, we manufactured ultrasmall dopamine-modified hyaluronic acid (HD)-stabilized Fe(III)-tannic acid nanoparticles (HFTNPs). HFTNPs can specifically accumulate in inflammatory macrophages in atherosclerotic plaques, provide brighter magnetic resonance images, promote reactive oxygen species (ROS) generation, and induce the death of inflammatory macrophages without damaging normal cells and tissues. In conclusion, HFTNPs have a tremendous potential as safe and effective diagnostic and therapeutic reagents for atherosclerosis.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei 230027, China

Department of Cardiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing 210008, China

Department of Cardiology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210023, China

Institute of Brain Science, Nanjing University, Nanjing, Jiangsu 210008, China

Funding

Jiangsu Province Postdoctoral Science Foundation · Ministry of Education of the People's Republic of China · China Postdoctoral Science Foundation · Government of Jiangsu Province · Nanjing University · Jiangsu Provincial Commission of Health and Family Planning · Six Talent Peaks Project in Jiangsu Province · National Natural Science Foundation of China · Nanjing Medical Science and Technique Development Foundation

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