journal article·2020-03-18Open access

Biofunctional Silk Kirigami With Engineered Properties

Sayantan Pradhan, Leonardo Ventura, Francesca Agostinacchio, Meng Xu, Ettore Barbieri, Antonella Motta, Nicola M. Pugno, Vamsi K. Yadavalli

ACS Applied Materials & Interfaces· Volume 12· Issue 11

Abstract

The fabrication of multifunctional materials that interface with living environments is a problem of great interest. A variety of structural design concepts have been integrated with functional materials to form biodevices and surfaces for health monitoring. In particular, approaches based on kirigami-inspired cuts can engineer flexibility in materials through the creation of patterned defects. Here, the fabrication of a biodegradable and biofunctional "silk kirigami" material is demonstrated. Mechanically flexible, free-standing, optically transparent, large-area biomaterial sheets with precisely defined and computationally designed microscale cuts can be formed using a single-step photolithographic process. Using modeling techniques, it is shown how cuts can generate remarkable "self-shielding" leading to engineered elastic behavior and deformation. As composites with conducting polymers, flexible, intrinsically electroactive sheets can be formed. Importantly, the silk kirigami sheets are biocompatible, can serve as substrates for cell culture, and be proteolytically resorbed. The unique properties of silk kirigami suggest a host of applications as transient, "green", functional biointerfaces, and flexible bioelectronics.
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Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Silk-based biomaterials and applications · Advanced Materials and Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 W Main Street, Richmond, Virginia 23284, United States

School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom

BIOtech Research Center, Department of Industrial Engineering, University of Trento, 38122 Trento, Italy

Japan Agency for Marine-Earth Science and Technology, Center for Mathematical Science and Advanced Technology, Computational Science and Engineering Group, 3173-25, Showa-machi, Kanazawa-ku, Yokohama, Kanagawa 236-0001, Japan

Laboratory of Bio-inspired, Bionic, Nano, Meta Materials & Mechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, 38122 Trento, Italy

Fondazione Edoardo Amaldi, Via del Politecnico snc, 00133 Rome, Italy

Funding

European Commission · Japan Society for the Promotion of Science · Division of Chemical, Bioengineering, Environmental, and Transport Systems · Ministero dell'Istruzione, dell'Universit? e della Ricerca

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